Prevalence of herpesvirus DNA in MS patients and healthy blood donors

Acta Neurologica Scandinavica
Roberto Alvarez-LafuenteRafael Arroyo

Abstract

The aim of this study is to determine the DNA prevalence of different members of Herpesviridae in multiple sclerosis (MS) patients and to describe the possible effect of beta-interferon treatment on such prevalence. With a nested polymerase chain reaction (PCR) assay we have studied the DNA of the peripheral blood mononuclear cells (PBMCs) of 204 whole blood samples, [102 from patients with relapsing-remitting MS (RRMS), of which 62 were treated with beta-interferon, and 102 from healthy blood donors]. We only found a statistically significant difference for human herpesvirus type 6 (HHV-6) DNA prevalence (P < 0.0001): HHV-6 is 2.26 times more frequent in MS patients than in healthy donors. There was no difference in the HHV-6 prevalence between beta-interferon treated and untreated patients. 1. Among the herpesviruses, HHV-6 was the only one showing altered prevalence. This either indicates that HHV-6 is involved in the pathogenesis of MS, or it simply indicates that MS influences latency or reactivation of HHV-6 without any direct involvement of HHV-6 in the disease process of MS. 2. Treatment with beta-interferon does not make a difference on the DNA prevalence of the herpesviruses studied in our MS patients.

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Citations

Nov 19, 2002·Journal of Medical Virology·Svetlana ChapenkoModra Murovska
Jul 17, 2008·Epilepsia·William H TheodoreSteven Jacobson
Jan 18, 2005·Clinical Microbiology Reviews·Leen De BolleErik De Clercq
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Nov 28, 2012·Journal of Neurovirology·Nadia Ben-FredjElisabetta Caselli
Jul 22, 2004·Current Infectious Disease Reports·Mary T. Caserta
Feb 6, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Julie FotheringhamSteven Jacobson
Apr 29, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Abbas Behzad-BehbahaniNegar Azarpira
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Jun 23, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Haijing LiYi-Wei Tang
Oct 25, 2008·Clinical Neurology and Neurosurgery·Mayela Rodríguez-ViolanteTeresa Corona
Apr 15, 2006·Brain Pathology·Roberto Alvarez-LafuenteRafael Arroyo
Feb 19, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gloudina M HonTandi Matsha
Nov 13, 2020·Clinical Microbiology Reviews·Anthony L KomaroffSteven Jacobson

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