Abstract
High fractional exhaled nitric oxide (FeNO) is an indicator of poor asthma control and has been proposed as a non-invasive assessment tool to guide asthma management. We aimed to describe the prevalence of and factors associated with high FeNO among US youth with asthma. Data from 716 children and adolescents with asthma ages 6-19 years who participated in the 2007-2012 National Health and Nutrition Examination Survey were analyzed. Using American Thoracic Society guidelines, high FeNO was defined as >50 ppb for ages 12-19 years and >35 ppb for ages 6-11 years. Multivariate logistic regression examined associations between high FeNO and age, sex, race/Hispanic origin, income status, weight status, tobacco smoke exposure, and other factors associated with asthma control (recent use of inhaled corticosteroids, recent respiratory illness, asthma-related respiratory signs/symptoms, and spirometry). About 16.5% of youth with asthma had high FeNO. The prevalence of high FeNO was higher among non-Hispanic black (27%, P < 0.001) and Hispanic (20.2%, P = 0.002) youth than non-Hispanic white (9.7%) youth. Differences in high FeNO prevalence by sex (girls < boys), weight status (obese < normal weight), tobacco smoke exposure (smokers < ho...Continue Reading
References
Feb 1, 1993·Pediatric Pulmonology·X WangB G Ferris
Mar 1, 1997·The Journal of Pediatrics·B V NelsonB Gaston
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Mar 26, 2003·Experimental Lung Research·Jeffrey C HoytPeter J Barnes
Aug 13, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ting Fan LeungTai Fai Fok
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Frederik BuchvaldHans Bisgaard
Oct 3, 2006·The European Respiratory Journal·P J FranklinS M Stick
Oct 11, 2007·Chest·Thomas KovesiRobert Dales
Mar 5, 2008·BMC Pediatrics·Gary T C KoJuliana C N Chan
Aug 30, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Barzin KhaliliSami L Bahna
Nov 13, 2008·Pediatric Pulmonology·Tom Kovesi, Robert Dales
Jun 27, 2009·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Thomas A Kovesi, Robert E Dales
Oct 7, 2009·Allergy·Y LaoudiJ Just
Dec 8, 2009·Brain, Behavior, and Immunity·Edith ChenGregory E Miller
Mar 26, 2010·Thorax·Martha ScottGraham Roberts
Sep 17, 2010·Proceedings of the American Thoracic Society·Anne E DixonUNKNOWN American Thoracic Society Ad Hoc Subcommittee on Obesity and Lung Disease
Oct 27, 2010·Pharmacotherapy·Silvia PandoLucie Blais
Aug 9, 2011·The Journal of Allergy and Clinical Immunology·Kenneth B QuintoSandra C Christiansen
Sep 3, 2011·American Journal of Respiratory and Critical Care Medicine·Raed A DweikUNKNOWN American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications
Feb 18, 2012·BMC Medical Research Methodology·Fredi A Diaz-Quijano
Aug 11, 2012·Chest·Robin J GreenRefiloe Masekela
Apr 23, 2013·Respiratory Medicine·James F Donohue, Neal Jain
Sep 12, 2013·Academic Pediatrics·Lara J AkinbamiAlan E Simon
Sep 18, 2013·Respiratory Medicine·Debra J BrodyCharles F Dillon
Jun 13, 2014·American Journal of Respiratory and Critical Care Medicine·Yueh-Ying HanJuan C Celedón
Aug 6, 2014·The Journal of Allergy and Clinical Immunology·Lara J AkinbamiKenneth C Schoendorf
Sep 5, 2014·Pediatric Pulmonology·S Voorend-van BergenM W Pijnenburg
Dec 17, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giuseppe Di CaraAlberto Verrotti
Jul 15, 2015·Pediatric Pulmonology·Brian K KitLara J Akinbami
Sep 25, 2016·The Journal of Allergy and Clinical Immunology·Joseph D SpahnStanley J Szefler