Prevalence of HIV type-1 drug-associated mutations in pre-therapy patients in the Free State, South Africa.

Antiviral Therapy
Kuan-Hsiang Gary HuangBloemfontein-Oxford Collaborative Group

Abstract

We aimed to characterize the molecular epidemiology of HIV type-1 (HIV-1) and the prevalence of drug-associated mutations prior to initiating highly active antiretroviral therapy (HAART) in the Free State province, South Africa. The Free State has a population of 3 million, an antenatal HIV prevalence of approximately 34% and a well established infrastucture for antiretroviral (ARV) provision. HIV-1 polymerase genes were sequenced from 425 HAART-naive HIV-1-positive patients at voluntary primary healthcare HIV testing centres, who were subsequently attending district centres for assessment for commencing ARVs. Patients (>18 years) were sampled randomly with no exclusion for gender or clinical criteria. Sequences were analysed according to phylogeny and drug resistance. Phylogenetic clustering within the cohort was suggestive of multiple introductions of subtype C virus into the region. Drug resistance mutations (according to the International AIDS Society-USA classification) were distributed randomly across the cohort phylogeny with an overall prevalence of 2.3% in the sampled patients. When stratified according to CD4(+) T-cell count, the prevalence of resistance was 3.6%, 0.9% and 1.2% for CD4(+) T-cell counts <100, 200-350 a...Continue Reading

Citations

Jan 19, 2012·AIDS Research and Human Retroviruses·Justen ManasaUNKNOWN Southern Africa Treatment And Resistance Network (SATuRN)
Jan 29, 2011·AIDS Patient Care and STDs·Krisda ChaiyachatiTill Bärnighausen
Mar 2, 2012·Journal of Virology·Jonathan M CarlsonDavid Heckerman
Oct 25, 2012·PloS One·Philippa C MatthewsPhilip J R Goulder
Dec 17, 2009·AIDS·UNKNOWN Paediatric European Network for Treatment of AIDS
Jul 11, 2019·Nature Communications·Duncan S PalmerGil McVean
Sep 10, 2016·Retrovirology·M-H TsaiP J R Goulder
Apr 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippa C MatthewsPhilip J R Goulder
May 18, 2016·Nature Medicine·Jonathan M CarlsonPaul A Goepfert

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