PMID: 8943744Oct 1, 1996Paper

Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis

Journal of Clinical Pathology
J A HammerlingD R Carrigan

Abstract

Human herpesvirus type 6 (HHV-6) is the aetiological agent of exanthem subitum, and has also been linked with a variety of other diseases. The aim of this study was to investigate the role of HHV-6 in pneumonitis in children. Formalin fixed, paraffin wax embedded lung tissue from 33 children (age range two months to 16 years) who died with pneumonitis was subjected to immunohistochemical staining for HHV-6 using an avidin-biotin method. Active HHV-6 infection was demonstrated in four children: a bone marrow transplant recipient with concomitant adenovirus infection, a patient with hepatitis of unknown aetiology, a patient with congenital anomalies, and a patient with congenital immunodeficiency. Accurate localisation of HHV-6 is possible in postmortem lung tissue. HHV-6 either alone or in combination with other pathogens may play a role in the development of pneumonitis.

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Citations

Nov 16, 2004·Journal of Medical Virology·Keizo YamamotoYukihiro Nishiyama
Jan 14, 2000·Critical Reviews in Oncology/hematology·M Peiris
Oct 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Samson S Y Wong, Kwok-Yung Yuen
Nov 5, 2011·Reviews in Medical Virology·Philip E PellettRaymund R Razonable
Dec 12, 2012·PloS One·Erin McElvania TeKippeGregory A Storch
Sep 6, 2005·Chemical & Pharmaceutical Bulletin·Chih-Yang ChiuTian-Shung Wu
Aug 25, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Matthias SchneiderKlaus Rauber
Dec 17, 2010·World Journal of Hepatology·Raymund R Razonable, Irmeli Lautenschlager

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