PMID: 25773853Mar 17, 2015Paper

Prevalence of human papillomavirus types and phylogenetic analysis of HPV-16 L1 variants from Southern India

Asian Pacific Journal of Cancer Prevention : APJCP
Shama Prasada KabekkoduKapaettu Satyamoorthy

Abstract

The human papillomavirus (HPV) and its variants show wide geographical distribution and have been reported to cause cervical lesions. With cervical neoplasia as the leading cancer in Indian women, the aim of the present study was to evaluate the multiple infection HPV type distribution and variant genotypes in cervical samples from the coastal Karnataka region, India. A total of 212 samples were screened by nested polymerase chain reaction using PGMY9/11 and GP5+/6+ primers. HPV positive samples were sequenced to identify the types and a phylogenetic tree was constructed using the neighbor-joining method. Sequence analysis identified a total of 14 HPV types distributed in 20%, 73.3% and 82.5% of non-malignant, pre-malignant [low grade squamous intraepithelial lesion (LSIL) and high grade squamous intraepithelial lesion (HSIL)] and cervical cancer samples. The distribution of high risk HPV in cancer samples was HPV 16, 76.4%, HPV18, 11.7%, HPV81, 2.9%, HPV31, 1.4%, HPV35, 1.4% and HPV 45, 1.4%. Multiple infections were observed in 11.8% of tumor samples with HPV 16 contributing to 62.5% of cases. In non-malignant samples, 20% of HPV positive samples were detected with HPV16, 82.3%, HPV33, 5.8% and HPV58, 5.8% and very low incide...Continue Reading

References

Jun 5, 2002·Nature Reviews. Cancer·Harald zur Hausen
Oct 19, 2004·Journal of Virological Methods·Andrea L Fuessel HawsStephen K Tyring
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Janet G Baseman, Laura A Koutsky
Apr 1, 2008·Journal of Biosciences·Cheryl M TravassoChandan Kumar-Sinha
Apr 3, 2009·The New England Journal of Medicine·Rengaswamy SankaranarayananKetayun A Dinshaw
Aug 28, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hugo De VuystSilvia Franceschi
Oct 19, 2010·The Lancet Oncology·Silvia de SanjoseUNKNOWN Retrospective International Survey and HPV Time Trends Study Group
Feb 14, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tania TaboneSepehr N Tabrizi
Apr 12, 2012·Journal of Virology·Iris CornetUNKNOWN IARC HPV Variant Study Group
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Palika DattaNeeta Singh
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Sreejata Raychaudhuri, Sukanta Mandal
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Saumya Pandey Chandrawati
Sep 19, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Krishnakumar VinodhiniKalimuthusamy Natarajaseenivasan
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Sreejata Raychaudhuri, Sukanta Mandal
Dec 5, 2012·Vaccine·David FormanSilvia Franceschi
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Sitakan NatphopsukTakafumi Ishida
Mar 29, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jissa Vinoda ThulaseedharanRengaswami Sankaranarayanan
May 7, 2013·Infectious Agents and Cancer·Ghazi AlsbeihIsmail Al-Badawi
Feb 12, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Joana RibeiroHugo Sousa
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Avdhesh Kumar RaiMousumi Sharma
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Seda TezcanGurol Emekdas
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Kannika PaengchitSomkiet Lalitwongsa

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Citations

Feb 7, 2017·The Journal of Obstetrics and Gynaecology Research·Sasidharanpillai SabeenaGovindakarnavar Arunkumar
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Samatha BhatKapaettu Satyamoorthy
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Sasidharanpillai SabeenaGovindakarnavar Arunkumar
Mar 4, 2017·Virchows Archiv : an International Journal of Pathology·Samatha BhatKapaettu Satyamoorthy

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