Abstract
Huntington's disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (HTT) CAG trinucleotide repeat alleles of 36 or more units. A greater than expected prevalence of incompletely penetrant HTT CAG repeat alleles observed among individuals diagnosed with major depressive disorder raises the possibility that another mood disorder, bipolar disorder, could likewise be associated with Huntington's disease. We assessed the distribution of HTT CAG repeat alleles in a cohort of individuals with bipolar disorder. HTT CAG allele sizes from 2,229 Caucasian individuals diagnosed with DSM-IV bipolar disorder were compared to allele sizes in 1,828 control individuals from multiple cohorts. We found that HTT CAG repeat alleles > 35 units were observed in only one of 4,458 chromosomes from individuals with bipolar disorder, compared to three of 3,656 chromosomes from control subjects. These findings do not support an association between bipolar disorder and Huntington's disease.
References
Dec 1, 1994·Human Molecular Genetics·F SquitieriJ Goto
Jan 1, 1994·International Journal of Psychiatry in Medicine·M F Mendez
Aug 1, 1994·Nature Genetics·D C RubinszteinM A Ferguson-Smith
Jun 1, 1993·Molecular and Cellular Probes·J P WarnerD J Brock
Dec 25, 2002·Bioinformatics·S PurcellP C Sham
Dec 21, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Camille L JulienDavid Craufurd
Mar 5, 2008·Molecular Psychiatry·P SklarS M Purcell
Nov 26, 2009·Human Molecular Genetics·Ihn Sik SeongMarcy E MacDonald
Dec 17, 2009·American Journal of Human Genetics·Daniel Falush
Apr 3, 2010·The American Journal of Psychiatry·Roy H PerlisJames Gusella
Jan 21, 2011·European Journal of Human Genetics : EJHG·Simon C WarbyMichael R Hayden
Feb 11, 2012·Neurology·J-M LeeUNKNOWN COHORT study of the HSG
Mar 14, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Eliana Marisa RamosJohn E Landers
Aug 7, 2012·International Journal of Methods in Psychiatric Research·Ronald C KesslerHans-Ullrich Wittchen
Aug 29, 2012·Neurology·N Ahmad AzizMarcy E Macdonald
Citations
Dec 12, 2017·Translational Psychiatry·Sarah L GardinerN Ahmad Aziz
Aug 24, 2017·European Journal of Human Genetics : EJHG·Michael J ChaoJong-Min Lee
Jun 9, 2016·Psychiatric Genetics·John B Vincent
Jul 12, 2020·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ignazio Stefano PirasAntonio M Persico
Nov 14, 2019·International Journal of Molecular Sciences·Václav Brázda, Miroslav Fojta