Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder

Bipolar Disorders
Eliana Marisa RamosRoy H Perlis

Abstract

Huntington's disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (HTT) CAG trinucleotide repeat alleles of 36 or more units. A greater than expected prevalence of incompletely penetrant HTT CAG repeat alleles observed among individuals diagnosed with major depressive disorder raises the possibility that another mood disorder, bipolar disorder, could likewise be associated with Huntington's disease. We assessed the distribution of HTT CAG repeat alleles in a cohort of individuals with bipolar disorder. HTT CAG allele sizes from 2,229 Caucasian individuals diagnosed with DSM-IV bipolar disorder were compared to allele sizes in 1,828 control individuals from multiple cohorts. We found that HTT CAG repeat alleles > 35 units were observed in only one of 4,458 chromosomes from individuals with bipolar disorder, compared to three of 3,656 chromosomes from control subjects. These findings do not support an association between bipolar disorder and Huntington's disease.

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Citations

Dec 12, 2017·Translational Psychiatry·Sarah L GardinerN Ahmad Aziz
Aug 24, 2017·European Journal of Human Genetics : EJHG·Michael J ChaoJong-Min Lee
Jul 12, 2020·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ignazio Stefano PirasAntonio M Persico
Nov 14, 2019·International Journal of Molecular Sciences·Václav Brázda, Miroslav Fojta

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