Abstract
Given the large number of patients with thyroid nodules, improvement of the specificity of current ultrasound-based thyroid nodule classification systems (ATA, EU-TIRADS, and ACR-TIRADS) is warranted to reduce the number of diagnostic thyroidectomies. Thyroid scintigraphy has been shown to demonstrate hyperfunctional nodules, associated with a low malignancy risk, in euthyroid patients. However, it is not known if thyroid scintigraphy could improve specificity of current classification systems. The aim of this study, therefore, was to determine the frequency of hyperfunctional nodules among those nodules in need of fine needle aspiration cytology (FNA) according to current classification systems and to test if nodule functional status is associated with sonographic features. Five hundred sixty-six euthyroid patients (TSH 0.55-4.20 μU/ml) presenting for thyroid nodule workup including thyroid sonography and scintigraphy at our department between 09/2013 and 02/2018 were included in this retrospective study. All nodules > 10 mm were classified according to ATA, EU-TIRADS, and ACR-TIRADS and correlated to their functional status as assessed by 99mTc-pertechnetate scintigraphy. Ultrasound detected 1029 thyroid nodules ≥ 10 mm, incl...Continue Reading
References
Sep 1, 1996·Der Pathologe·S Schröder, B Marthaler
Jul 20, 2002·Annals of Nuclear Medicine·Masahiro IwataJunji Konishi
Aug 23, 2002·European Journal of Nuclear Medicine and Molecular Imaging·J Meller, W Becker
Oct 22, 2004·The New England Journal of Medicine·Laszlo Hegedüs
Jul 12, 2005·Endocrine Journal·Takafumi MajimaKazuwa Nakao
Aug 17, 2006·Thyroid : Official Journal of the American Thyroid Association·Eugenio ReschiniPaolo Gerundini
Jul 16, 2009·European Journal of Clinical Investigation·S GuthC M Bamberger
May 26, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hossein GharibUNKNOWN AACE/AME/ETA Task Force on Thyroid Nodules
Jun 1, 2010·Otolaryngologic Clinics of North America·Steven R BomeliRobert L Ferris
Jun 11, 2011·Pathology Research International·Rabia BasharatTahira Hamid
Jul 21, 2011·Radiology·Jin Young KwakEun-Kyung Kim
Jul 27, 2011·Nuklearmedizin. Nuclear Medicine·Rainer GörgesL Freudenberg
Oct 4, 2012·Deutsche medizinische Wochenschrift·D GrafK Mann
May 7, 2013·Thyroid Research·Sasan MirfakhraeeJeffrey M Zigman
Jan 24, 2014·European Journal of Endocrinology·Rayan ChamiBernard Corvilain
May 6, 2015·European Journal of Clinical Investigation·Giorgio TregliaLuca Giovanella
Oct 16, 2015·Thyroid : Official Journal of the American Thyroid Association·Bryan R HaugenLeonard Wartofsky
Aug 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossMartin A Walter
Apr 5, 2017·Journal of the American College of Radiology : JACR·Franklin N TesslerA Thomas Stavros
Jun 15, 2017·PloS One·Sabrina JegerlehnerUNKNOWN NICER Working Group
Nov 24, 2017·European Thyroid Journal·Gilles RussLaurence Leenhardt
Jan 15, 2018·International Journal of Surgery Case Reports·Maria João LimaAntónio Taveira-Gomes
Mar 3, 2018·Radiology·Jenny K HoangFranklin N Tessler
Aug 12, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Simone SchenkeRainer Görges
Oct 16, 2018·Nuclear Medicine Communications·Pedro W RosarioMaria R Calsolari
Citations
Aug 11, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Katrin Brauckhoff, Martin Biermann
Jun 21, 2020·Sensors·Martin FreesmeyerPhilipp Seifert
Nov 6, 2020·Diagnostic Cytopathology·Pedro Weslley Rosario, Theara de Castro Nicolau
Dec 23, 2020·Clinical Endocrinology·Ilenia PirolaCarlo Cappelli
Feb 14, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Giuliano MarianiH William Strauss