Prevalence of hypertension after living-donor liver transplantation: a prospective study

Transplantation Proceedings
M-S TongC-L Hang

Abstract

Hypertension is common among patients who have undergone liver transplantation and is a major contributor to cardiovascular events. Few studies have studied the risk factors associated with post-liver transplantation (LT) hypertension. This prospective study assessed the prevalence of post-LT hypertension and associated preoperative risk factors. From May 2008 to December 2009, 79 normotensive adult patients (≥ 18 years old) who underwent living-donor LT with a median follow up of 4.79 ± 0.88 years were enrolled. Patients' pre-LT demographics, clinical data, pre-LT diabetes, and immunosuppressive agents used after LT were studied for their association with post-LT hypertension. The prevalence of post-LT hypertension was 49.4%. The independent risk factors for post-living-donor LT hypertension were pre-LT systolic blood pressure (SBP; odds ratio [OR], 1.04; 95% confidence interval [CI], 1.00-1.09; P = .039) and post-LT administration of mammalian target of rapamycin (mTOR) inhibitors (OR, 4.08; 95% CI, 1.40-11.94; P = .010). Pre-LT diabetes had a negative predictive value (OR, 0.15; 95% CI, 0.03-0.74; P = .019). Neither age, male sex, smoking, pre-LT serum cholesterol and triglyceride levels, tacrolimus, nor glucocorticoid was a...Continue Reading

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Citations

Aug 11, 2018·Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization·David R RutkowskiAlejandro Roldán-Alzate
Aug 11, 2020·World Journal of Gastroenterology : WJG·Tian ShenXiao Xu
Mar 23, 2021·Journal of Clinical and Experimental Hepatology·Narendra S ChoudharyArvinder S Soin

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