Abstract
Optimizing the multimodality treatment of malignant pleural mesothelioma depends on many factors including an adequate chemotherapeutic response. Currently, chemotherapy regimens for patients with mesothelioma are empirically selected. In vitro chemotherapy resistance in human mesothelioma has not been reported. Our goal was to determine the prevalence of drug resistance in a large sample of malignant pleural mesothelioma using a commercially available assay. Tumors specimens (n = 203) were cultured for analysis of chemoresistance using the extreme drug resistance assay. Evaluable results were obtained in 168 (168/203 = 83%) specimens. Each specimen was tested with 3 drugs: cisplatin, gemcitabine, and vinorelbine. Drug resistance was characterized as low, intermediate, or extreme. Median age was 64 years (30-85 years). Forty-four (26%) patients received neoadjuvant chemotherapy before sampling and testing. The distribution of histopathologic cell types was epithelial (103; 61%), mixed (57; 34%), and sarcomatoid (8; 5%). A significant proportion of tumors had extreme/intermediate drug resistance to cisplatin (27%), gemcitabine (31%), or vinorelbine (59%). Nineteen tumors (11%) had extreme/intermediate resistance to all 3 drugs. ...Continue Reading
References
Apr 4, 1990·Journal of the National Cancer Institute·D H Kern, L M Weisenthal
Dec 31, 1998·The Journal of Thoracic and Cardiovascular Surgery·D J SugarbakerS J Mentzer
Aug 21, 2001·Breast Cancer Research and Treatment·R S MehtaJ P Fruehauf
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J VogelzangPaolo Paoletti
Nov 25, 2003·American Journal of Obstetrics and Gynecology·Vera LoizziMichael L Berman
Aug 4, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deborah SchragUNKNOWN ASCO Working Group on Chemotherapy Sensitivity and Resistance Assays
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John P Fruehauf, David S Alberts
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan P van MeerbeeckUNKNOWN National Cancer Institute of Canada
Jan 24, 2006·The Annals of Thoracic Surgery·Thomas A d'AmatoRicardo J Parker
Mar 1, 2006·Molecular Cancer Therapeutics·Shrikanta ChattopadhyayI David Goldman
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Thomas A d'AmatoJames D Luketich
Nov 17, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sujith R KalmadiErnest C Borden
Jul 18, 2008·Gynecologic Oncology·J N McAlpineN M Spirtos
Jan 9, 2009·Annals of Surgical Oncology·John M LyonsEugene A Woltering
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee M KrugNicholas J Vogelzang
Citations
Nov 19, 2013·Oncogene·M CioceG Blandino
May 31, 2011·The Journal of Thoracic and Cardiovascular Surgery·Stefan B WatzkaMichael R Müller
Jan 11, 2013·Journal of Cellular and Molecular Medicine·Giulia PintonLaura Moro
Oct 16, 2016·Molecular Pharmaceutics·Amr S Abu LilaTatsuhiro Ishida
Nov 3, 2016·PloS One·Antonella MuscellaSanto Marsigliante
Dec 17, 2014·Nanoscale·Nabil El BrahmiJean-Pierre Majoral
Jul 14, 2017·PloS One·Antonella MuscellaSanto Marsigliante
Oct 25, 2011·Oncogene·C CaninoM Cioce
Jan 10, 2018·Oncogene·Simona di MartinoMario Cioce
Oct 26, 2011·ChemMedChem·Ilaria ZanellatoDomenico Osella
Jan 31, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Mauro RaveraDomenico Osella
Apr 15, 2015·Oncotarget·Claudia CaninoMario Cioce
Aug 17, 2018·BMC Cancer·Myung-Chul KimYongbaek Kim
Aug 11, 2019·Journal of Experimental & Clinical Cancer Research : CR·Claudio PulitoSabrina Strano
Dec 30, 2014·Oncotarget·Iris Chiara SalaroglioChiara Riganti
Nov 1, 2012·Thoracic Cancer·Vincenzo AmbrogiUNKNOWN Multidisciplinary Tor Vergata University Study Group for Malignant Pleural Mesothelioma
Oct 27, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laurel M SchunselaarJacques Neefjes
Aug 24, 2019·Redox Biology·Zan LiShinya Toyokuni
Nov 4, 2021·Journal of Experimental & Clinical Cancer Research : CR·Mario CioceVito Michele Fazio