Prevalence of inhibitors and clinical characteristics in patients with haemophilia in a middle-income Latin American country

Haemophilia : the Official Journal of the World Federation of Hemophilia
Laura Villarreal-MartínezElias Adán Godoy-Salinas

Abstract

Development of inhibitors is the most serious complication in patients with haemophilia (PWH). The prevalence of inhibitors in patients with severe haemophilia A (HA) is approximately 25%-30%. Inhibitor prevalence differs among populations. Some studies report a prevalence of almost twice in Hispanic as compared to Caucasian patients. Most data available, on the prevalence of inhibitors and their predisposing factors, originate from centres in developed countries. Establish the prevalence of inhibitors of FVIII and FIX in Mexico. This was an observational, cross-sectional and descriptive study. The records of all patients diagnosed with haemophilia A (HA) or B (HB), with and without inhibitors, were included. Clinical and demographical characteristics of patients with inhibitors were assessed. Statistical analysis was performed using IBM SPSS version 22. The Ethics Committees of the various participating institutions approved this study. A total of 1455 patients from the 20 participating centres were recruited, from which 1208 (83.02%) had HA and 247 (16.97%) were diagnosed with HB. The presence of inhibitors in severe HA was reported in 93/777(11.96%), and 10/162 (6.17%) in severe HB. Of them, 91.7% exhibited high titres in HA...Continue Reading

References

Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·L M Aledort, D M Dimichele
May 31, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·J AstermarkUNKNOWN MIBS Study Group
Jun 5, 2003·Lancet·Paula H B Bolton-Maggs, K John Pasi
May 13, 2006·Seminars in Hematology·Cindy A Leissinger
May 13, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·J A AznarV R Cortina
Mar 25, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·X F WangH L Wang
Nov 15, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·K E WebertI R Walker
Nov 23, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·C H MillerUNKNOWN Hemophilia Inhibitor Research Study Investigators
Jan 19, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·S L CarpenterUNKNOWN Hemophilia Treatment Center Network (HTCN) Investigators
Aug 23, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·M MakrisR D'Oiron
Sep 11, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·J SchwarzUNKNOWN Hemophilia Inhibitor Genetics Study Combined Cohort
Dec 12, 2012·Blood·Jan AstermarkUNKNOWN Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort
Jan 18, 2013·The New England Journal of Medicine·Samantha C GouwUNKNOWN PedNet and RODIN Study Group
Mar 29, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·L C RossettiC D De Brasi
Sep 17, 2013·Nature Medicine·Gouri Shankar PandeyUNKNOWN PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators
Aug 30, 2014·Journal of Internal Medicine·M Osooli, E Berntorp
Oct 8, 2014·Journal of Blood Medicine·Adriana Aparecida FerreiraMaximiliano Ribeiro Guerra
Dec 2, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Patricia PintoShrimati Shetty
Jan 7, 2015·European Journal of Haematology·Edit Bardi, Jan Astermark
Jul 7, 2015·American Journal of Hematology·Connie H MillerUNKNOWN Hemophilia Inhibitor Research Study Investigators
Apr 28, 2017·International Journal of Laboratory Hematology·J D Lai, D Lillicrap
Jul 12, 2017·The New England Journal of Medicine·Johannes OldenburgMidori Shima
Jul 12, 2017·The New England Journal of Medicine·K John PasiMargaret V Ragni
Dec 7, 2017·Thrombosis and Haemostasis·Maria Elisa MancusoUNKNOWN European Pediatric Network for Haemophilia Management (PedNet) the REMAIN (REal life MAnagement of children with INhibitors)
Jun 8, 2018·Thrombosis Research·Isabella GaragiolaFlora Peyvandi
Jun 12, 2018·European Journal of Haematology·Lucia S D'AngiolellaLorenzo G Mantovani
Nov 15, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Sachin DavidVikram Mathews
Nov 16, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sayed H MousaviSirous Zeinali
Apr 30, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Manuel CarcaoUNKNOWN Future of Immunotolerance Treatment Group
May 10, 2019·British Journal of Haematology·Guy Young

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Nov 16, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Daniela NemeMauro Davoli

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