Prevalence of iron deficiency in children with Down syndrome.

The Journal of Pediatrics
Natalia E DixonPriya S Kishnani

Abstract

To determine the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) in a sample of children with Down syndrome (DS) and to evaluate the effect of macrocytosis on the diagnosis of ID/IDA in these children. Children with DS ≥ 12 months of age who were followed at the Duke University Medical Center Comprehensive DS Clinic from December 2004 to March 2007 were screened for ID/IDA with a complete blood count, reticulocyte count, iron panel, and erythrocytic protoporphyrins. A total of 114 children were enrolled, with a median age of 4.7 years. ID was identified in 12 subjects (10%), and IDA was identified in 3 subjects (3%). ID/IDA would not have been accurately diagnosed in 13 of 15 subjects (86%) if red blood cell (RBC) indices alone had been used for screening. Abnormal RBC indices with low transferrin saturation were 100% sensitive for ID/ IDA screening. Prevalence of ID/IDA in children with DS was comparable with that in the general pediatric population. Macrocytosis had implications for screening of ID/IDA with only RBC indices. We suggest ID/IDA screening in DS children be done with a laboratory panel at least including complete blood count, reticulocyte count, transferrin saturation, and serum ferritin.

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Citations

Sep 24, 2011·International Journal of Pediatrics·Ariel TenenbaumPolina Stepensky
Nov 2, 2016·Asian-Australasian Journal of Animal Sciences·Jae-Bong LeeHyun-Tae Lim
Aug 17, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sarah J HartPriya S Kishnani
Nov 26, 2019·Metallomics : Integrated Biometal Science·Nakisa MalakootiPaul A Adlard
Oct 9, 2019·Journal of Developmental and Behavioral Pediatrics : JDBP·Shruti MittalAngela LaRosa
Apr 28, 2020·American Journal of Medical Genetics. Part a·George CaponeUNKNOWN Down Syndrome Medical Interest Group (DSMIG-USA) Adult Health Workgroup
Jun 11, 2020·The New England Journal of Medicine·Marilyn J Bull
Mar 28, 2018·Oxidative Medicine and Cellular Longevity·Romina María Uranga, Gabriela Alejandra Salvador
Aug 20, 2021·Indian Journal of Pediatrics·Mandula Phani PriyaMadhulika Kabra

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