Prevalence of left ventricular hypertrabeculation/noncompaction among children with sickle cell disease

Congenital Heart Disease
M Louise MorrisonColin J McMahon

Abstract

Incidence of sickle cell disease (SCD) in Ireland has dramatically increased. Disease survival has also steadily improved however cardiovascular manifestations remain important causes of morbidity. These include reports of left ventricular hypertrabeculation (LVHT)/noncompaction. We sought to investigate the prevalence of LVHT among a large cohort of children with SCD. We retrospectively reviewed the records of all patients with a diagnosis of SCD who had undergone surveillance echocardiography at Our Lady's Children's Hospital Crumlin (OLCHC) from 1998 to 2015. Demographics, hemoglobin phenotype and treatment information was recorded. LV systolic function, evidence of LVHT, and possible pulmonary arterial hypertension was assessed. Two hundred thirty-six patients had echocardiograms available for interpretation. One hundred twenty-one (51.3%) were female; mean age was 11.3 years (± 4.1 years). Twenty-six patients (11%) had features of LVHT on echocardiography. Eleven patients (4.7%) had borderline features of LVHT. Mean LVEDD across the whole cohort was 4.2 ± 0.69 cm, LVEDD z-score of 1.44 ± 1.9, and mean LVSF was 37.3% ±15.7%. There were no significant differences in terms of age, LVEDD, LVEDD z-score, or LVSF between patient...Continue Reading

References

Jan 1, 1997·Mayo Clinic Proceedings·M RitterR Jenni
Sep 5, 2002·American Journal of Hematology·Anjan S BatraPierre C Wong
Jun 30, 2004·American Journal of Hematology·Shahid AhmedLinda A Russo
May 30, 2006·European Journal of Heart Failure·Peter Alter, Bernhard Maisch
Dec 15, 2006·European Journal of Heart Failure·Josef Finsterer, Claudia Stöllberger
Feb 25, 2009·International Journal of Cardiology·Ze-Zhou Song
Feb 22, 2012·The American Journal of Cardiology·Ahmad Charaf EddineSethuraman Swaminathan
Mar 24, 2012·Journal of the American College of Cardiology·Mark T Gladwin, Vandana Sachdev
Feb 22, 2016·JACC. Cardiovascular Imaging·Omar NissMichael D Taylor
Nov 15, 2016·Cardiology in the Young·Philippe M AdjagbaNagib Dahdah

❮ Previous
Next ❯

Citations

Dec 24, 2019·Frontiers in Molecular Biosciences·Giulia CeglieGiuseppe Palumbo
Jul 16, 2021·Progress in Cardiovascular Diseases·Fatemeh AdabifirouzjaeiAnthony Nicholas DeMaria

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.