Prevalence of major depression one year after predictive testing for Huntington's disease

Genetic Testing
Ann-Marie CodoriJason Brandt

Abstract

Psychiatric hospitalizations, completed suicides, and suicide attempts are rare after predictive testing for Huntington's disease (HD). Case studies have shown that major depression can be a consequence of being tested, although no studies have shown how common this is. The present study evaluated the prevalence of major depression during the first year after disclosure. We conducted retrospective data and chart reviews of 153 persons (50 testing positive, 103 testing negative) evaluated every 3 months for depression. There was no significant baseline difference in the percentage of "positives" and "negatives" who had pre-testing major depressive episodes (14% vs. 12%, respectively). A senior psychiatrist reviewed data from the Schedule for Affective Disorders and Schizophrenia-Change Version, from the Beck Depression Inventory, and from clinical notes for every follow-up contact completed. The 1-year prevalence of major depression among positives was 6.0%, compared to 3.0% among negatives (p = 0.30), and an estimated 3% population prevalence. One-year prevalence of clinically significant depressive symptoms, whether or not major depression was diagnosed, was 20.0% in positives and 12.6% in negatives (p = 0.17). Although not st...Continue Reading

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Citations

Sep 13, 2006·Journal of Genetic Counseling·Maria U LarssonTarja-Brita Robins Wahlin
Feb 24, 2007·Journal of Genetic Counseling·Milena PanequeJorge Sequeiros
Jun 15, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Hyman M Schipper
Jun 29, 2010·Current Protocols in Human Genetics·Jeffrey R Botkin
Aug 20, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Noelle E CarlozziJane S Paulsen
Apr 17, 2009·International Psychogeriatrics·Camilla HawKeith Hawton
Jul 7, 2005·European Journal of Human Genetics : EJHG·Marleen DecruyenaereJean-Pierre Fryns
Oct 9, 2009·Genetic Testing and Molecular Biomarkers·Maria Elisa AlonsoAstrid Rasmussen
Apr 1, 2017·Journal of Genetic Counseling·Aysegül IbislerSabine Hoffjan
Aug 20, 2019·Journal of Huntington's Disease·Noelle E CarlozziRebecca E Ready
Apr 23, 2008·Current Protocols in Human Genetics·Jeffrey R Botkin
Apr 23, 2015·Nursing Ethics·Petra Lilja AnderssonAnna-Karin Edberg
Nov 18, 2020·Current Protocols in Human Genetics·Jeffrey R Botkin

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