Prevalence of malignant hyperthermia diagnosis in hospital discharge records in California, Florida, New York, and Wisconsin

Journal of Clinical Anesthesia
Zhen LuGuohua Li

Abstract

Malignant hyperthermia (MH) is a rare yet potentially fatal pharmacogenetic disorder triggered by exposure to inhalational anesthetics and the depolarizing neuromuscular blocking agent succinylcholine. Epidemiologic data on the geographic variation in MH prevalence is scant. The objective of this study is to examine the prevalence of recorded MH diagnosis in patients discharged from hospitals in four states in the United States. Observational study. Healthcare Cost and Utilization Project (HCUP) State Inpatient Database (SID) for California (2011), Florida (2011), New York (2012) and Wisconsin (2012). A total of 164 hospital discharges that had a recorded diagnosis of MH using the International Classification of Disease, 9th Revision, Clinical Modification code 995.86. MH prevalence was assessed by patient demographic and clinical characteristics. The prevalence of MH per 100,000 hospital discharges ranged from 1.23 (95% Confidence Interval [CI], 0.80-1.66) in New York to 1.91 (95% CI, 1.48-2.34) in California, and the prevalence of MH per 100,000 surgical discharges ranged from 1.47 (95% CI, 0.93-2.02) in New York to 2.86 (95% CI, 2.00-3.71) in Florida. The prevalence of MH in male patients was more than twice the prevalence i...Continue Reading

Citations

Mar 31, 2018·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Sheila RiaziPhilip M Hopkins
Jul 18, 2018·Current Opinion in Neurology·Bram De Wel, Kristl G Claeys
Jan 1, 2020·Anesthesia Progress·Bryant W CorneliusKelly S Kennedy
Dec 15, 2018·Anesthesiology·Marilyn Green LarachUNKNOWN Multicenter Perioperative Outcomes Group
May 26, 2018·Archives of Women's Mental Health·Heather Burrell WardMarcela Almeida
Apr 18, 2021·BMC Anesthesiology·Xiaodan Gong

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