PMID: 8608678Nov 1, 1995Paper

Prevalence of metacarpal osteopenia in young rheumatoid arthritis patients

Clinical Rheumatology
A A KallaR Laubscher

Abstract

The aim of this study was to assess the prevalence of and diagnostic role of metacarpal osteopenia in rheumatoid arthritis (RA) and to evaluate its detectability using receiver operating characteristic (ROC) analysis. Metacarpal bone mineral density was measured in 98 patients with classical RA using a computer-assisted measure of 6 metacarpal diameters (radiogrammetry) in patients aged less than 50 years. Sensitivity and specificity of the technique in discriminating the RA patients from 85 normal controls and osteopenic RA subjects from their normopenic counterparts, was determined by standard statistical techniques. Clinical, laboratory and radiological variables were compared in their ability to explain the variance of metacarpal bone density. The prevalence of metacarpal osteopenia in RA was 55%. Prolonged disease and reduced function significantly differentiated osteopenic from non-osteopenic RA patients. Discriminant analysis of RA and control groups showed that measurement of 6 metacarpals was more accurate than the 2nd metacarpal measurement alone in predicting the RA patients. The sum of 6 metacarpal combined cortical width (CCW) had a sensitivity of 61% and specificity of 68% in discriminating the RA patients from th...Continue Reading

References

Jul 1, 1977·Acta Radiologica: Diagnosis·N Fredensborg, B E Nilsson
Nov 1, 1976·The British Journal of Radiology·J Dequeker
Jun 1, 1992·Baillière's Clinical Rheumatology·A K Bhalla, B Shenstone
Jul 1, 1991·Clinical Physiology·J HaarboC Christiansen
Apr 1, 1991·British Journal of Rheumatology·A D Woolf
Apr 1, 1991·British Journal of Rheumatology·N F PeelR G Russell
Dec 1, 1989·British Journal of Rheumatology·A A KallaT J Kotze
Jan 1, 1986·Southern Medical Journal·W J AlexanderW L Roper
Sep 1, 1988·Annals of the Rheumatic Diseases·A A KallaN D Parkyn
Aug 1, 1988·Annals of the Rheumatic Diseases·J E CompstonM M O'Sullivan
May 1, 1987·Arthritis and Rheumatism·A P Kaplan
Jul 1, 1987·Arthritis and Rheumatism·P N SambrookS Eberl
Apr 1, 1986·Annals of the Rheumatic Diseases·J T HallaJ G Hardin
Jan 1, 1985·Medical Decision Making : an International Journal of the Society for Medical Decision Making·R M Centor
Jan 1, 1985·Medical Decision Making : an International Journal of the Society for Medical Decision Making·R M Centor, J S Schwartz
Sep 1, 1985·Calcified Tissue International·F BaussR Ziegler
Mar 1, 1972·The British Journal of Radiology·E NaorJ Menczel
Jul 1, 1972·Annals of Internal Medicine·M SinghJ Jowsey
Mar 1, 1970·The American Journal of Clinical Nutrition·J H Wilmore, A R Behnke
Nov 1, 1965·Annals of the Rheumatic Diseases·B A CastilloJ T Scott
Sep 1, 1967·Journal of Applied Physiology·A W Sloan
Oct 1, 1967·Arthritis and Rheumatism·P D Saville, O Kharmosh
Oct 27, 1983·The New England Journal of Medicine·L IannuzziI Kushner
Aug 1, 1984·Arthritis and Rheumatism·A J CrispS M Krane
Jul 1, 1994·Arthritis and Rheumatism·N F PeelR Eastell
Dec 1, 1993·Arthritis and Rheumatism·M Jergas, H K Genant
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN

❮ Previous
Next ❯

Citations

Oct 2, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Jun IwamotoShoichi Ichimura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.