Abstract
Some minimal changes (MCs) are believed to have a certain relationship with gastroesophageal reflux (GERD). Nonetheless, the individual meaning of MC is still unclear. Our aim was to compare the overall and individual prevalence of MC between patients with non-erosive reflux disease (NERD) and healthy controls (HC). Twelve endoscopic findings in the esophagogastric junction were prospectively compared between NERD (n = 64) and control (n = 104). Overall frequency of MC (≥ 1 out of 12 criteria) was higher in the NERD group (71.9%) than in the HC group (45.2%). In individual analysis, white mucosal turbidity, irregular Z-line, horizontal erosions, and mucosal protrusion of cardia were significantly more common in the NERD group compared to controls. Among them, only white mucosal turbidity was independently associated with the NERD group (OR 3.97, 95% CI 1.72-9.13). Individuals with male gender, reflux symptoms, higher height, current smoking, ethanol intake and hiatal hernia were more likely to have white mucosal turbidity compared to the group without white turbidity. MC could be a useful marker to support clinical diagnosis of GERD. White mucosal turbidity in particular might be a GERD-specific sign related to acid-induced muc...Continue Reading
References
Oct 20, 1999·Archives of Internal Medicine·R FassM B Fennerty
Sep 24, 2004·Digestive Diseases·R KiesslichP R Galle
Jun 10, 2005·Alimentary Pharmacology & Therapeutics·T NakamuraA Terano
Mar 29, 2006·Journal of Gastroenterology·Michio Hongo
Aug 25, 2006·The American Journal of Gastroenterology·Nimish VakilUNKNOWN Global Consensus Group
Oct 24, 2006·Endoscopy·Y AmanoY Kinoshita
Jan 20, 2007·Endoscopy·A EdeboL Lundell
Aug 3, 2007·Journal of Gastroenterology·Takashi JohUNKNOWN ARS Research Group
Jan 22, 2008·Journal of Gastroenterology and Hepatology·Jun Haeng LeeUNKNOWN H.pylori and GERD Study Group of Korean College of Helicobacter and Upper Gastrointestinal Research
May 15, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H MiwaS Himeno
Jul 23, 2008·Journal of Clinical Gastroenterology·Anita Gasiorowska, Ronnie Fass
Oct 10, 2008·Digestion·Changcheng Wang, Richard H Hunt
Oct 20, 2010·Alimentary Pharmacology & Therapeutics·S GaddamP Sharma
Mar 3, 2011·Endoscopy·J H KimUNKNOWN MIGHT study group
Citations
Mar 20, 2013·Digestive Diseases and Sciences·Jae Gu JungJin Ho Lee
Jan 27, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Han Seung Ryu, Suck Chei Choi
Oct 8, 2015·Journal of Clinical Gastroenterology·Scott L GabbardRam Dickman
Mar 2, 2016·The American Journal of Surgical Pathology·Genevieve SoucyRobert D Odze
Oct 30, 2013·Gut·Rebecca C FitzgeraldUNKNOWN British Society of Gastroenterology
Oct 21, 2016·Frontline Gastroenterology·David GrahamLaurence B Lovat
Apr 11, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Ana Carolina Ferreira Ratin, Ivan Roberto Bonotto Orso
Oct 12, 2018·Endoscopy International Open·Pei DengYan Liu
Nov 1, 2020·Medicine·Jae Ho ChoDong Ho Lee
Aug 6, 2021·Therapeutic Advances in Gastrointestinal Endoscopy·Fujino JunkoRichard Couper