Prevalence of multidrug-resistant pulmonary tuberculosis in counties with different duration of DOTS implementation in rural China

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Y HuBiao Xu

Abstract

This study aimed to describe the prevalence of drug-resistant tuberculosis (TB) among pulmonary TB patients in rural China and to determine the extent of multidrug-resistant TB (MDR-TB) circulating in areas with varied duration of Directly Observed Treatment, Short Course (DOTS) implementation. A cross-sectional study was conducted in two rural counties in eastern China: Deqing with over 10 years' DOTS implementation and Guanyun under its second year of DOTS. The subjects were all culture-positive pulmonary TB patients newly diagnosed or re-treated during 12 months of 2004-2005. The proportion method was used for drug susceptibility testing. Among the 399 subjects, 283 were new TB cases and 116 were previously treated. The rates of overall resistance (i.e., resistance to at least one drug) in new cases were 50.4% (67) and 63.4% (95), respectively, in Deqing and Guanyun (p = 0.028), and 67.3% (33) and 83.6% (56), respectively, in previously treated cases (p = 0.0410). The rates of MDR-TB in new cases were 3.8% (5) in Deqing and 14.7% (22) in Guanyun (p = 0.0018), and 16.3% (8) and 34.3% (23) in previously treated cases (p = 0.0305). Newly diagnosed and previously treated TB patients from the short-term DOTS-covered county were a...Continue Reading

References

May 18, 2000·JAMA : the Journal of the American Medical Association·M A EspinalM C Raviglione
Jan 5, 2002·The Korean Journal of Internal Medicine·J H Lee, J H Chang
Oct 3, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S K SharmaN K Mehra
Aug 31, 2004·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Ernesto Montoro Cardoso
Jul 18, 2006·The Journal of Infectious Diseases·Matteo ZignolChristopher Dye
Aug 31, 2006·Health Policy and Planning·B XuL Bogg
Dec 19, 2006·Lancet·Mohamed Abdel AzizUNKNOWN WHO/International Union Against Tuberculosis And Lung Disease Global Project on Anti-tuberculosis Drug Resistance Surveillan

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Citations

Mar 11, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Aiping ZhouYufeng Yao

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