Prevalence of multiple sclerosis in Sardinia: A systematic cross-sectional multi-source survey.

Multiple Sclerosis : Clinical and Laboratory Research
Silvana Am UrruMS Working Group

Abstract

Partial surveys in sub-regions of Sardinia have suggested a high prevalence of multiple sclerosis (MS) on the island, relative to other Mediterranean populations. We assessed the island-wide prevalence of MS and its detailed distribution in Sardinia. The study population consisted of 5677 MS patients, 1735 men and 3942 women, living in Sardinia. Neurologists retrospectively examined electronic and paper-based records of patients with a diagnosis of MS. The data were then linked to the administrative health information systems. Crude, age-, and sex-specific prevalence estimates of disease were calculated. The overall age-adjusted MS prevalence was 330 per 100,000 (95% confidence interval (CI) 321-338) in individuals older than 15 years, 447 in women (95% CI 433-461), and 205 in men (95% CI 195-214). The prevalence was highest in the Ogliastra and Nuoro districts, respectively, 425 (95% CI 372-478) and 419 (95% CI 387-451), and lowest in the Olbia-Tempio district, 217 (95% CI 195-239). Most cases had relapsing-remitting MS (79.3%), 16.3% had secondary-progressive MS, and 4.4% had primary-progressive MS. These prevalence are among the highest reported so far worldwide. They provide estimates for comparative analyses in other popul...Continue Reading

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jan 6, 1999·Acta Neurologica Scandinavica·I CasettaM Pugliatti
Jan 12, 2001·Acta Neurologica Scandinavica·M PugliattiG Rosati
Jul 20, 2002·Clinical Neurology and Neurosurgery·Maura PugliattiGiulio Rosati
Jul 2, 2005·Neuroepidemiology·Maura PugliattiGiulio Rosati
Jul 13, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M PugliattiI Milanov
Feb 16, 2008·Lancet Neurology·George C Ebers
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·S A WarrenK G Warren
Jul 9, 2008·Neurology·Alvaro Alonso, Miguel A Hernán
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Jan 26, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Antonio Cao, Renzo Galanello
Apr 20, 2010·Lancet Neurology·Nils Koch-Henriksen, Per Soelberg Sørensen
Nov 13, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Alessandra NicolettiMario Zappia
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 9, 2011·BMC Medical Research Methodology·Alison BeauchampAnna Peeters
Apr 12, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Steve SimpsonBruce Taylor
Jun 10, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Eleonora CoccoMaria G Marrosu
May 12, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Elizabeth M VisserCarl E Counsell
Jun 20, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Inger BoströmAnne-Marie Landtblom
Oct 1, 2013·Nature Genetics·UNKNOWN International Multiple Sclerosis Genetics Consortium (IMSGC)Jacob L McCauley
Apr 27, 2016·Seminars in Neurology·Alberto Ascherio, Kassandra L Munger
Jul 15, 2016·PloS One·Olivia ErnstssonAnders Norlund
Apr 27, 2017·The New England Journal of Medicine·Maristella SteriFrancesco Cucca
Sep 19, 2018·Nature Genetics·Charleston W K ChiangJohn Novembre

❮ Previous
Next ❯

Citations

Mar 21, 2020·Brain and Behavior·Tamás BiernackiKrisztina Bencsik
Dec 25, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Roberto BergamaschiCristina Montomoli
Mar 29, 2020·Neurology. Neuroimmunology and Neuroinflammation·Johannes Sverre WillumsenRune Midgard
Nov 12, 2020·Multiple Sclerosis and Related Disorders·L LoreficeE Cocco
Dec 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Patrick OstkampUNKNOWN German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network
May 4, 2021·Developmental Medicine and Child Neurology·Anna EusebiStefano Sotgiu
Nov 25, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M PonzioF Ansaldi
Jan 14, 2022·Seminars in Immunopathology·Woori Kim, Nikolaos A Patsopoulos

❮ Previous
Next ❯

Software Mentioned

STATA
AnagS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.