Prevalence of mycobacteremia in Indian HIV-infected patients detected by the MB/BacT automated culture system

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Krishnamoorthy GopinathSarman Singh

Abstract

The use of automated blood cultures system, such as MB/BacT, has provided a novel opportunity for laboratories to diagnose mycobacteremia in HIV-infected patients. However, no such study has been carried out in India so far. This prospective study was conducted on 52 HIV-positive patients with suspected tuberculosis who were referred to our tertiary care hospital in New Delhi. In these patients, the prevalence of mycobacteremia was evaluated using the MB/BacT automated culture system (bioMérieux, France). Twenty-seven HIV-negative but suspected tuberculosis patients were also included for comparison. Mycobacteria could be isolated from sputa or fecal samples of 20 HIV-positive patients (38.4%), and in nine (45%) of these 20 cases, mycobacteria could also be isolated simultaneously from their blood specimens. In the remaining 32 patients, all relevant non-hematological clinical samples remained negative for mycobacteria, but the pathogen could be detected from the blood samples of seven (21.87%) of these 32 patients. Therefore, only 25 (48%) clinically suspected patients remained negative in both Löwenstein-Jensen (L-J) and MB/BacT culture methods, and 12 of these responded to anti-tubercular treatment, while in the rest either ...Continue Reading

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Citations

Jul 16, 2008·Annals of Clinical Microbiology and Antimicrobials·Manimuthu Mani SankarSarman Singh
Feb 9, 2012·The Indian Journal of Medical Research·Surendra K Sharma, Manish Soneja
Dec 21, 2011·Asian Pacific Journal of Tropical Medicine·A D KhosraviS Seghatoleslami
Aug 29, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H M El SahlyE A Graviss
Sep 12, 2009·PloS One·Angela CannasUNKNOWN TB trDNA consortium
Jan 23, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Jul 3, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Viswas ChhapolaVirendra Kumar
Jan 22, 2011·Molecular Diagnosis & Therapy·Sathish SankarGopalan Sridharan

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