Prevalence of Mycobacterium tuberculosis resistance to quinolones and injectables in Colombia, 2012-2013

Biomédica : revista del Instituto Nacional de Salud
Claudia LlerenaMartha Murcia

Abstract

Tuberculosis is a health problem worldwide. The World Health Organization estimated 9.6 million new cases and 480,000 multirresistant cases for 2014. The assessment of resistance to quinolones and injectables was implemented only a few years ago, so its prevalence is not known. To determine the prevalence of resistance to amikacin, capreomycin and ofloxacin in cases of tuberculosis resistant to isoniazid and/or rifampin during 2012-2013. This was a cross-sectional study of 489 isolates resistant to isoniazid and/or rifampin. We used the Bactec MGITTM technique for susceptibility tests. For analyzing the rate of resistance, we grouped cases according to the history of treatment with second line drugs. In the 438 new cases, the drug that showed greater overall resistance was kanamycin with 7.1 % (95% CI: 4.6 to 9.6). In 51 previously treated cases, this highest resistance was 27.5 % (95% CI:14.2 to 40.7). The overall resistance was higher in cases with a history of treatment with quinolones and injectables. We found seven cases of extremely resistant tuberculosis. This study demonstrates the presence of resistance to second line drugs in people with drug-resistant tuberculosis with and without previous treatment with quinolones a...Continue Reading

References

Apr 1, 1996·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·J AlcaideL Salleras
Aug 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jennifer HoVitali Sintchenko
Aug 7, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mayara L BastosUNKNOWN Collaborative Group for Meta-analysis of Individual Patient Data in MDR-TB
Jan 20, 2015·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Nana LiHong Zhang
Mar 27, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kauser JabeenRumina Hasan
Dec 3, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Nafees AhmadAmer Hayat Khan
Dec 4, 2015·Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología·Diego Abelardo Álvarez-HernándezRosalno Vázquez-López
Apr 30, 2016·International Journal of Mycobacteriology·Kausar JabeenRumina Hasan

❮ Previous
Next ❯

Citations

Dec 21, 2019·Biomédica : revista del Instituto Nacional de Salud·Angie Zabaleta, Claudia Llerena
May 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhijun ZhuangZhenkun Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.