Prevalence of natural rubber latex allergy (type I and type IV) in laboratory workers in The Netherlands

Contact Dermatitis
H de GrootT van Joost

Abstract

The objective of the study was to study the prevalence of Type IV and Type I allergy to natural rubber latex (NRL) in a population at risk in the Netherlands. Laboratory workers regularly using gloves were invited to complete a questionnaire and to be tested. We performed patch tests with standard contact allergens, rubber additives, glove powder and pieces of 4 gloves; prick tests with inhalant allergens, glove extracts, glove powder and fruit extracts; and RASTs. Glove-related hand dermatitis was reported in 36.9% of the individuals interviewed. A positive patch test result for rubber additives was seen in only 6.6%. Glove-related urticaria, rhinoconjunctivitis and/or asthma were reported in 24.6% of all cases. Confirmation of an IgE-mediated reaction was achieved in 8.3% by prick test with glove extracts and 5.0% by RAST. No reaction to glove powder was noticed in patch testing or in prick testing. A high prevalence rate of glove-related symptoms and NRL Type I allergy was found in laboratory workers exposed to rubber gloves. Surprisingly, there was no co-existence of Type I and Type IV allergy in this population.

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Citations

Feb 5, 2000·Occupational and Environmental Medicine·J SmedleyD Coggon
May 7, 2004·Contact Dermatitis·Kristiina AlankoLasse Kanerva
Apr 3, 2004·Contact Dermatitis·Eustachio NettisAntonio Ferrannini
May 20, 2003·The British Journal of Dermatology·M M U Chowdhury, B N Statham
Apr 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E NettisA Tursi
Apr 6, 2005·Clinical and Experimental Dermatology·T H Clayton, S M Wilkinson
Jun 15, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Anna E KershSalma de la Feld
Aug 13, 1999·Contact Dermatitis·K F Thomson, S M Wilkinson
Apr 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G C M GroenewoudR Gerth van Wijk

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