Prevalence of neurogenetic disorders in the North of England

Neurology
David BargielaPatrick F Chinnery

Abstract

Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence. Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England. Monogenic neurologic disorders affect at least 90.9/100,000 (95% confidence interval 87.6-94.3), or 1 in 1,100 of the population in Northern England. As a group, neurogenetic disorders are not rare. These findings have implications for clinical service delivery.

References

Jan 1, 1991·Neuromuscular Disorders : NMD·A E Emery
Apr 4, 2003·The New England Journal of Medicine·Robert L Nussbaum, Christopher E Ellis
Jun 14, 2003·Brain : a Journal of Neurology·Daniela SkladalDavid R Thorburn
May 4, 2004·Annals of Neurology·Kate CraigPatrick F Chinnery
Jul 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·M B MuzaimiN P Robertson
Oct 15, 2005·Journal of the Neurological Sciences·Kate CraigPatrick F Chinnery
May 23, 2006·Lancet Neurology·Lonneke M L de Lau, Monique M B Breteler
Feb 10, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Mélissa FrédéricGwenaelle Collod-Béroud
Sep 22, 2007·Annals of Neurology·Andrew M SchaeferDouglass M Turnbull
Sep 22, 2009·Brain : a Journal of Neurology·Fiona L M NorwoodVolker Straub
Apr 27, 2010·Ophthalmology·Patrick Yu-Wai-ManPatrick F Chinnery
Nov 5, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Susan ByrneOrla Hardiman
Aug 19, 2011·Human Heredity·Ammar Al-Chalabi, Cathryn M Lewis
Sep 24, 2011·Lancet Neurology·Andrew B Singleton
Oct 11, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Charlotte FoleyRita Horvath
Mar 9, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Susan ByrneOrla Hardiman
Mar 14, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Stephen J W EvansLiam Smeeth
Aug 7, 2013·Ophthalmology·Patrick Yu-Wai-Man, Patrick F Chinnery
Apr 4, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Amina ChaouchHanns Lochmüller
Feb 6, 2015·Annals of Neurology·Gráinne S GormanRobert McFarland
Feb 15, 2015·Neurology·Gerald PfefferPatrick F Chinnery

❮ Previous
Next ❯

Citations

Sep 6, 2015·Neurology·Bryan J Traynor, Corrado Angelini
May 14, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Martha A Nance
Aug 11, 2016·Neurodegenerative Disease Management·Sheharyar Sajjad BaigOliver Wj Quarrell
Mar 24, 2016·The British Journal of Ophthalmology·Patrick Yu-Wai-Man
Dec 31, 2017·FEBS Letters·Veronika BoczonadiRita Horvath
Sep 13, 2017·Children·Laura Beth Mann DosierZheng Fan
Oct 5, 2018·Journal of Neurology·Roisin SullivanHenry Houlden
Jan 28, 2021·Annual Review of Medicine·Bhavya RaviCharlotte J Sumner
Jan 6, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Ikhlass Haj SalemNicolas Dupré
Jun 8, 2021·Frontiers in Neurology·Ungsoo Samuel KimPatrick Yu-Wai-Man

❮ Previous
Next ❯

Related Concepts

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Related Papers

Journal of Medical Genetics
C O Carter
Nihon rinsho. Japanese journal of clinical medicine
Shiro Ikegawa
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry
Z L Liu
© 2021 Meta ULC. All rights reserved