Prevalence of Neutralizing Antibodies to Japanese Encephalitis Virus among High-Risk Age Groups in South Korea, 2010

PloS One
Eun Ju LeeYoung Eui Jeong

Abstract

After an extensive vaccination policy, Japanese encephalitis (JE) was nearly eliminated since the mid-1980s in South Korea. Vaccination in children shifted the affected age of JE patients from children to adults. However, an abrupt increase in JE cases occurred in 2010, and this trend has continued. The present study aimed to investigate the prevalence of neutralizing antibodies to the JE virus (JEV) among high-risk age groups (≥40 years) in South Korea. A plaque reduction neutralization test was conducted to evaluate the prevalence of neutralizing antibodies to JEV in 945 subjects within four age groups (30-39, 40-49, 50-59, and 60-69 years) in 10 provinces. Of the 945 enrolled subjects, 927 (98.1%) exhibited antibodies against JEV. No significant differences were found in the prevalence of neutralizing antibodies according to sex, age, or occupation. However, there were significant differences in the plaque reduction rate according to age and occupation; oldest age group had a higher reduction rate, and subjects who were employed in agriculture or forestry also had a higher value than the other occupations. We also found that three provinces (Gangwon, Jeonnam, and Gyeongnam) had a relatively lower plaque reduction rate than t...Continue Reading

References

Jun 1, 1985·The Journal of Infectious Diseases·D S BurkeS Chantavibul
Aug 4, 1999·The American Journal of Tropical Medicine and Hygiene·Y C WuG R Wang
Feb 14, 2003·Journal of Virology·Tom SolomonAlan D T Barrett
May 29, 2004·Trends in Pharmacological Sciences·Jagadeesh BayrySrini V Kaveri
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pietro CaramelloAntonino Di Caro
Feb 26, 2009·Medical and Veterinary Entomology·S Y KimY R Ju
Feb 6, 2010·Progress in Neurobiology·Usha Kant Misra, Jayantee Kalita
Jan 1, 2009·International Journal of General Medicine·Viroj Wiwanitkit
Sep 29, 2011·Virology Journal·Ratree TakhampunyaBrian P Evans
Nov 16, 2011·Bulletin of the World Health Organization·Grant L CampbellAmy S Ginsburg
Apr 14, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Dong-Woo LeeJong-Koo Lee
Jun 20, 2012·Journal of Medical Virology·Tatjana BaldovinVincenzo Baldo
Jun 1, 2011·Osong Public Health and Research Perspectives·Young Eui JeongYoung Ran Ju
Jul 25, 2014·PLoS Neglected Tropical Diseases·Li-Ching HsuFeng-Yee Chang
Nov 13, 2014·Osong Public Health and Research Perspectives·Go Woon ChaYoung Eui Jeong
Feb 11, 2015·The Journal of General Virology·Ruchi SrivastavaEdouard Cantin

❮ Previous
Next ❯

Citations

Sep 21, 2016·Emerging Infectious Diseases·Jun-Sang SunwooKon Chu
Aug 26, 2016·PLoS Neglected Tropical Diseases·Jin-Ren PanShu-Yun Xie
Mar 17, 2017·Human Vaccines & Immunotherapeutics·Nagendra R Hegde, Milind M Gore
Aug 23, 2017·The American Journal of Tropical Medicine and Hygiene·Jun-Sang SunwooKon Chu
Aug 24, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hee-Jung LeeYoung Bong Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

PASW Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.