Abstract
By using colorimetric tests, reports have indicated that occult gastrointestinal bleeding is common in celiac disease. These results suggest that bleeding is a significant contributor to iron deficiency in this disorder and imply a significant inflammatory hemorrhagic component. Both these concepts are contrary to previous understanding of pathology of celiac disease. Furthermore, colorimetric tests provide an indirect and nonspecific assessment of blood loss. We therefore hypothesized that an accurate, quantitative, and specific method for blood loss, rather than a guaiac test, might give different findings. We report the results of stool blood loss measurement by using such a method. We measured stool blood loss directly by using 51Cr radiolabeled red cells in 18 consecutive patients with celiac disease who consented to the study, 12 with total villous atrophy and 6 with partial villous atrophy, before initiation of a gluten-free diet. Average daily blood loss exceeded 1.5 mL in only 1 of 18 subjects. It is suspected, but unproven, that this subject had an alternate transient source of gastrointestinal bleeding. Colorimetric tests give a high prevalence of positive results for occult gastrointestinal blood loss in celiac dise...Continue Reading
Citations
Sep 14, 2006·Current Gastroenterology Reports·Lincoln Hernandez, Peter H Green
Sep 16, 2006·Blood·Thorvardur R HalfdanarsonJoseph A Murray
Sep 30, 2009·World Journal of Gastroenterology : WJG·Fernando Fernández-BañaresMontserrat Forné
Jan 1, 2011·Case Reports in Gastrointestinal Medicine·M Gwiggner, P Patel
Feb 19, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Joseph A MurrayChristine E McLaren
May 3, 2007·Gastroenterology Clinics of North America·Susan H BartonJoseph A Murray
Jul 22, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Selim Gokce, Esra Arslantas
Aug 26, 2015·The American Journal of Gastroenterology·Lauren B GersonJonathan A Leighton
Apr 9, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Susan F Clark
Mar 31, 2010·Nature Reviews. Gastroenterology & Hepatology·Don C Rockey
Nov 8, 2013·Annals of Medicine·Roberta CarusoGiovanni Monteleone
Aug 7, 2012·Scandinavian Journal of Gastroenterology·Atallah BaydounAli T Taher
Aug 27, 2015·World Journal of Gastroenterology : WJG·Hugh James Freeman
Nov 30, 2018·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Neha BerryRakesh Kochhar
May 8, 2018·British Journal of Haematology·Gaetano BergamaschiGino R Corazza
Feb 23, 2020·Nutrients·Johanna M KreutzAnita C E Vreugdenhil
May 1, 2021·Nutrients·Miguel A Montoro-HuguetManuel Domínguez-Cajal
Aug 24, 2020·Gastroenterology·Don C RockeyDenise Kalmaz
Aug 28, 2016·Pediatrics·John SnyderKimberly P Newton