Prevalence of overlap of antineutrophil cytoplasmic antibody associated vasculitis with systemic autoimmune diseases: an unrecognized example of poliautoimmunity

Clinical Rheumatology
Eduardo Martín-NaresAndrea Hinojosa-Azaola

Abstract

We aimed to estimate the frequency of overlap of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with systemic autoimmune diseases. Retrospective single-center study to identify patients with AAV diagnosis and concomitant autoimmune systemic diseases, simultaneously, before or after the diagnosis of AAV. Sociodemographic characteristics, such as comorbidities; follow-up time; type of AAV; disease duration; relapses; treatment and response; clinical, serological, and histological characteristics; disease activity and damage; prognosis; dialysis requirements, and death were assessed. Twenty-eight of two hundred and forty-seven patients (11.3%) with AAV had a concomitant diagnosis of autoimmune disease. The predominant AAV type was renal-limited vasculitis (39%), followed by granulomatosis with polyangiitis (29%), mycroscopic polyangiitis (25%), and eosinophilic granulomatosis with polyangiitis (7%). Mean age at AAV diagnosis was 50 ± 17 years and 24/28 were ANCA positive. The main clinical manifestations were renal (79%), otorhinolaryngologic (43%), and pulmonary and peripheral neuropathy (32%). Sixteen patients (57%) experienced partial or total remission at a median follow-up of 34 months, and four patien...Continue Reading

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Citations

Dec 29, 2020·The American Journal of Medicine·Fabian LeoChristian Grohé
Feb 7, 2021·Rheumatology·Eduardo Martín-Nares, Gabriela Hernandez-Molina
Apr 2, 2021·European Journal of Medical Research·Rui WuJing Zhu
Apr 20, 2021·Frontiers in Medicine·Riccardo CapecchiPaola Migliorini
Aug 25, 2021·Zeitschrift für Rheumatologie·Aaron JucheAndreas Krause
Aug 31, 2021·Clinical Reviews in Allergy & Immunology·Marco FolciEnrico Brunetta

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