Prevalence of Plasmodium falciparum antimalarial drug resistance genes in Southeastern Gabon from 2011 to 2014

Infection and Drug Resistance
Dominique Fatima Voumbo-MatoumonaJean Bernard Lekana-Douki

Abstract

The introduction of artemisinin-based combination therapies (ACTs) in treating uncomplicated malaria and sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment during pregnancy drastically decreased the burden of malarial disease around the world. However, ACTs are known to select for drug resistance markers. In Gabon, artemether-lumefantrine induced an increase in the prevalence of N86-Pfmdr1, which is associated with treatment failure. However, little data are available regarding resistance markers in Southeastern Gabon. This study aimed to evaluate the evolution of resistance haplotypes in the Pfcrt, Pfdhps, Pfdhfr, and PfK13 genes from 2011 to 2014 in Southeastern Gabon. A total of 233 Plasmodium falciparum DNA samples were collected from febrile pediatric patients in South Gabon: Franceville, an urban area; Koulamoutou, a semi-urban area; and Lastourville, a rural area. Pfcrt, Pfdhps, Pfdhfr, and the propeller domain of PfK13 were sequenced for all isolates. The overall prevalence (3.7%-11.5%) of the wild-type haplotype Pfcrt 72-76 CVMNK was not significantly different between 2011 and 2014 in Southeast Gabon. For Pfdhfr (codons 51, 59, 108, 164), the IRNI triple-mutant haplotype was the most prevalent (>89.0%...Continue Reading

Citations

Nov 17, 2019·International Journal of Molecular Sciences·Rita CapelaFrancisca Lopes
Jul 7, 2019·Scientific Reports·Tamirat Gebru WoldearegaiJana Held
May 24, 2019·Briefings in Functional Genomics·Annie N Cowell, Elizabeth A Winzeler
Mar 29, 2021·Journal of Global Antimicrobial Resistance·Fleuramie Mirembou BoukoumbaSandrine Lydie Oyegue-Liabagui
Jun 22, 2021·Emerging Infectious Diseases·Sarah E SchmedesEldin Talundzic

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Methods Mentioned

BETA
PCR

Software Mentioned

R
Vector NTI advanced ( TM )

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Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.