Prevalence of positive autoimmune biomarkers in the brucellosis patients

Clinical Rheumatology
Zahra AhmadinejadMahdi Ahmadinejad

Abstract

Brucellosis is a chronic infectious disease with articular involvement. Discrimination between brucellosis and rheumatologic disorders is difficult in regions endemic for brucellosis. There are few studies about the rate of positive autoantibodies as rheumatologic biomarkers in brucellosis, and the prevalence is variable. In this study, the rheumatologic tests were studied in brucellosis patients. This cross sectional study was performed in two teaching hospitals in Tehran, Iran. Forty-nine patients with brucella infection and 42 healthy participants were enrolled in this study. Brucellosis was diagnosed on the basis of the clinical symptoms and positive serology for brucellosis. Rheumatic factor (RF) and antinuclear antibodies (ANA) were evaluated in all patients. Cyclic citrullinated peptides antibody (ACPA) and anti-double strand DNA (anti-dsDNA) were checked in all patients and control groups. Out of 49 patients, 15 (30.6 %) were RF positive and 4 (8.2 %) were ANA positive. Anti-dsDNA was concurrently positive with ANA in 1 patient (2 %) but ACPA titer was positive in 8 patients (16.3 %). None of the patients with positive autoantibody biomarkers fulfilled the criteria for rheumatologic disorders. The rate of positive RF in...Continue Reading

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Citations

Feb 23, 2019·World Journal of Orthopedics·Seyed Mokhtar Esmaeilnejad-Ganji, Seyed Mohammad Reza Esmaeilnejad-Ganji
Aug 4, 2018·Case Reports in Rheumatology·Ramandeep BainsPhilip J Clements
Sep 21, 2021·PLoS Neglected Tropical Diseases·Siwen ZhangQing Zhen

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Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

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