Prevalence of Pseudobulbar Affect following Stroke: A Systematic Review and Meta-Analysis

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
David C GillespieNiall M Broomfield

Abstract

Several studies have reported that emotional lability is a common consequence of stroke. However, there is uncertainty about the "true" prevalence of the condition because, across these studies, patients have been recruited at different stages of recovery, from different settings, and using different diagnostic methods. There have been no systematic reviews of the published evidence to ascertain how the prevalence of poststroke pseudobulbar affect (PBA) might vary according to these factors. A systematic review and meta-analysis of the published literature were undertaken. A total of 15 studies (n = 3391 participants) met inclusion criteria for the review. Meta-analysis estimated that the prevalence of PBA was 17% (95% confidence interval 12%-24%) acutely (<1 month post stroke), 20% (14%-29%) post acutely (1-6 months post stroke), and 12% (8%-17%) in the medium to longer term (>6 months post stroke). The evidence from the published literature, although limited, is that crying is a more common PBA presentation following stroke than laughter. PBA is a common condition that affects approximately 1 in 5 stroke survivors at the acute and postacute phases, and 1 in 8 survivors beyond 6 months post stroke. These prevalence data are ve...Continue Reading

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Citations

Jul 3, 2018·PM & R : the Journal of Injury, Function, and Rehabilitation·Richard D ZorowitzJoao Siffert
Mar 20, 2019·The Cochrane Database of Systematic Reviews·Sabine AllidaMaree L Hackett
Sep 15, 2018·Topics in Stroke Rehabilitation·Tarun GirotraWuwei Feng
Oct 5, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·José M Ferro, Ana C Santos
Dec 22, 2020·Clinical Rehabilitation·Niall M BroomfieldMatthew Walters
May 29, 2019·Disability and Rehabilitation·Niamh McAleeseDavid C Gillespie
Jun 18, 2021·Clinical Rehabilitation·Niall M BroomfieldMatthew Walters
Nov 18, 2021·Disability and Rehabilitation·Sophie FitzgeraldNiall Broomfield
Dec 10, 2021·Continuum : Lifelong Learning in Neurology·Shae DattaJosepha Cheong

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