Prevalence of pulmonary hypertension and its association with respiratory disturbances in obese patients living at moderately high altitude

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
M Valencia-FloresD L Bliwise

Abstract

To determine the point prevalence of pulmonary hypertension (PH) and its relationship with respiratory disturbances in obese patients living at moderate altitude. A total of 57 obese patients comprised the final sample and consisted of 34 women and 23 men, with a mean age of 42.7+/-12.1 ys and a mean body mass index (BMI) 47.1+/-10.6 kg/m(2) (range from 30.1 to 76.1). The mean living altitude was 2248.7 m, range 2100-2400 m above sea level. Doppler echocardiography, pulmonary function tests, arterial blood gas analysis, and polysomnography were performed. Data showed that 96.5% of the studied sample had daytime PH defined as calculated systolic pulmonary artery pressure (PSAP) >30 mmHg (mean PSAP=50, s.d.=13 mmHg). The severity of diurnal PH was found to be related to the presence of alveolar hypoventilation and BMI. The main risk factor for severity of diurnal PH was hypoventilation with a significant odds ratio (OR) 7.96, 95% CI 1.35-46.84, BMI was (OR 1.12, 95% CI 1.02-1.25) and apnea/hypopnea index was not a predictor of pulmonary hypertension severity (OR 0.99, 95% CI 0.97-1.02). We concluded that prevalence of diurnal PH is high in obese patients living at moderate altitude, and that hypoventilation is the main risk facto...Continue Reading

References

Aug 1, 1988·The American Review of Respiratory Disease·E WeitzenblumD Kurtz
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Dec 1, 1994·The European Respiratory Journal·O MarroneG Bonsignore
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·D SajkovR D McEvoy
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y AllemannM Maggiorini
Oct 10, 2001·Clinics in Chest Medicine·M D McGoon
Apr 19, 2002·Journal of Applied Physiology·Tahnee A KinsmanChin-Moi Chow
Nov 1, 1956·The American Journal of Medicine·A G BICKELMANNR D WHALEY

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Citations

Sep 19, 2012·Journal of Obesity·Scott E Friedman, Bruce W Andrus
Jan 5, 2014·Cardiovascular Diabetology·Marcela Rodríguez-FloresCarlos Cantú-Brito
Aug 25, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·David Vearrier, Michael I Greenberg
Feb 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Mohammed M MinhajAndrew Maslow
Jan 3, 2006·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Rex A MarleyCarole Ries
Apr 22, 2015·Sleep & Breathing = Schlaf & Atmung·Tolga Sinan GüvençBahattin Balci
Jul 5, 2016·Frontiers in Physiology·Gregoire P MilletOlivier Girard
Aug 30, 2005·American Journal of Respiratory and Critical Care Medicine·Jean-Paul RichaletFabiola León-Velarde
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Ihab M Wahba, Robert H Mak
Apr 5, 2008·American Journal of Respiratory and Critical Care Medicine·Jean-Paul RichaletFabiola León-Velarde
Sep 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H VallyV Madan
May 19, 2010·Expert Review of Respiratory Medicine·Joshua O StreamColin K Grissom
Feb 12, 2020·Journal of Human Hypertension·Marijana Tadic, Cesare Cuspidi
Aug 16, 2017·Obesity Facts·Rocío San MartinFabiola León-Velarde

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