PMID: 338408Dec 1, 1977

Prevalence of residual B-cell function in insulin-treated diabetics evaluated by the plasma C-etide response to intravenous glucagon

C HendriksenC Binder


In 83 insulin-treated diabetics the influence of the duration of insulin treatment on the prevalence of residual insulin secretion was examined by determining the plasma C-peptide concentration before and after intravenous injection of 1 mg of glucagon. In 64 patients, plasma C-etide concentration was also determined before and after a standard meal. There was a good correlation between the C-peptide response to glucagon and to the meal (r = 0.67; p less than 0.0001) suggesting that the glucagon test will predict the B-cell response during everyday life. The predictive value of a positive glucagon test was 84% and of a negative test 100%. A preserved, but reduced, B-cell function was demonstrable in 36 of 83 patients. Residual B-cell function was most frequent in the patients with the shortest duration of diabetes. The metabolic importance of endogenous insulin was demonstrated by the significantly lower insulin requirement in the patients with residual B-cell function.

Associated Clinical Trials


Nov 1, 1979·Diabetologia·P McNairI Transbøl
Jan 1, 1979·Irish Journal of Medical Science·R Tattersall
Jan 1, 1992·Acta Psychiatrica Scandinavica·N KobayashiT Nakagawa
Jun 6, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Jan SchultessJens Dhein
Jan 1, 1981·Journal of Immunoassay·U KrauseJ Beyer
Jun 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·T Rönnemaa
Nov 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·P KoskinenP Seppälä
Nov 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·P KoskinenP Seppälä
Mar 23, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·R E J BesserA T Hattersley
Jun 7, 2005·Diabetes Research and Clinical Practice·M AlbaredaA Pérez
Feb 1, 1993·Diabetes Research and Clinical Practice·M T YilmazF Sipahioğlu
Feb 1, 1981·European Journal of Clinical Investigation·P McNairI Transbøl
Jan 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·S MadsbadC Binder
Jan 1, 1986·Diabetes/metabolism Reviews·O K Faber, C Binder
Jul 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·S Arnold-LarsenC Kühl
May 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·H J GjessingA Frøland
Aug 1, 1985·Diabetes Research and Clinical Practice·A Matsuda, T Kuzuya
May 29, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A CiresiC Giordano
Mar 13, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R PozzanM B Gomes
Feb 1, 1996·Medical Hypotheses·M I Wurzburger, P H Sönksen
Feb 6, 2018·Journal of Endocrinological Investigation·V GuarnottaC Giordano
Jan 1, 1986·Diabetes/metabolism Reviews·K S Polonsky, A H Rubenstein
Nov 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·P J GrantD W Miles
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·A M Bonser, P Garcia-Webb


Aug 1, 1976·Klinische Wochenschrift·W BeischerE F Pfeiffer
Jun 1, 1976·Hoppe-Seyler's Zeitschrift für physiologische Chemie·O K FaberC Binder
Dec 1, 1976·Diabetologia·J Ludvigsson, L G Heding
Jun 1, 1975·The Journal of Clinical Investigation·D L HorwitzA H Rubenstein
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·F MelaniD F Steiner

Related Concepts

Insulin B Chain
Islets of Langerhans
Diabetes Mellitus
Blood Glucose

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