PMID: 338408Dec 1, 1977Paper

Prevalence of residual B-cell function in insulin-treated diabetics evaluated by the plasma C-etide response to intravenous glucagon

Diabetologia
C HendriksenC Binder

Abstract

In 83 insulin-treated diabetics the influence of the duration of insulin treatment on the prevalence of residual insulin secretion was examined by determining the plasma C-peptide concentration before and after intravenous injection of 1 mg of glucagon. In 64 patients, plasma C-etide concentration was also determined before and after a standard meal. There was a good correlation between the C-peptide response to glucagon and to the meal (r = 0.67; p less than 0.0001) suggesting that the glucagon test will predict the B-cell response during everyday life. The predictive value of a positive glucagon test was 84% and of a negative test 100%. A preserved, but reduced, B-cell function was demonstrable in 36 of 83 patients. Residual B-cell function was most frequent in the patients with the shortest duration of diabetes. The metabolic importance of endogenous insulin was demonstrated by the significantly lower insulin requirement in the patients with residual B-cell function.

Associated Clinical Trials

References

Aug 1, 1976·Klinische Wochenschrift·W BeischerE F Pfeiffer
Jun 1, 1976·Hoppe-Seyler's Zeitschrift für physiologische Chemie·O K FaberC Binder
Dec 1, 1976·Diabetologia·J Ludvigsson, L G Heding
Jun 1, 1975·The Journal of Clinical Investigation·D L HorwitzA H Rubenstein
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·F MelaniD F Steiner

❮ Previous
Next ❯

Citations

Nov 1, 1979·Diabetologia·P McNairI Transbøl
Jan 1, 1979·Irish Journal of Medical Science·R Tattersall
Jan 1, 1992·Acta Psychiatrica Scandinavica·N KobayashiT Nakagawa
Jun 6, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Jan SchultessJens Dhein
Jan 1, 1981·Journal of Immunoassay·U KrauseJ Beyer
Jun 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·T Rönnemaa
Nov 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·P KoskinenP Seppälä
Nov 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·P KoskinenP Seppälä
Mar 23, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·R E J BesserA T Hattersley
Jun 7, 2005·Diabetes Research and Clinical Practice·M AlbaredaA Pérez
Feb 1, 1993·Diabetes Research and Clinical Practice·M T YilmazF Sipahioğlu
Feb 1, 1981·European Journal of Clinical Investigation·P McNairI Transbøl
Jan 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·S MadsbadC Binder
Jan 1, 1986·Diabetes/metabolism Reviews·O K Faber, C Binder
Jul 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·S Arnold-LarsenC Kühl
May 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·H J GjessingA Frøland
Aug 1, 1985·Diabetes Research and Clinical Practice·A Matsuda, T Kuzuya
May 29, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Alessandro CiresiCarla Giordano
Mar 13, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R PozzanM B Gomes
Feb 1, 1996·Medical Hypotheses·M I Wurzburger, P H Sönksen
Feb 6, 2018·Journal of Endocrinological Investigation·V GuarnottaC Giordano
Jan 1, 1986·Diabetes/metabolism Reviews·K S Polonsky, A H Rubenstein
Nov 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·P J GrantD W Miles
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·A M Bonser, P Garcia-Webb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.