Prevalence of restless legs syndrome in Parkinson's disease: a systematic review and meta-analysis of observational studies

Sleep Medicine
Xinglong YangZhong Xu

Abstract

Restless legs syndrome (RLS) and Parkinson's disease (PD) are common neurological disorders that respond to dopaminergic therapy. RLS prevalence among people with PD varies widely (0-38%) in the literature, complicating efforts to understand whether the two diseases might be associated. The databases Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were searched for observational and case-control studies of RLS prevalence in PD. Eligible studies were meta-analyzed using Stata 12.0. Pooled RLS prevalence in PD among various patient populations was 14%, and prevalence in Asia (12%) was slightly lower than outside Asia (16%). Prevalence was higher among patients who had previously received PD treatment (15%) than among drug-naïve patients (11%). Prevalence of RLS was higher in female PD patients (13%) than in male patients (11%). RLS prevalence was much higher among PD patients than among healthy controls (OR 2.86, 95% CI 2.10-3.90; p < 0.001). This meta-analysis may provide the first reliable pooled estimate of RLS prevalence in PD, and strong evidence that RLS risk is higher among PD patients than among healthy individuals.

Citations

Dec 7, 2019·Journal of Neurology·Lindsay H M Keir, David P Breen
Apr 21, 2019·Neurology·Hortensia Alonso-NavarroFélix Javier Jiménez-Jiménez
Mar 17, 2020·Journal of Neural Transmission·Roongroj BhidayasiriClaudia Trenkwalder
Feb 14, 2019·Arquivos de neuro-psiquiatria·Renato Puppi MunhozLaura Silveira-Moriyama
Nov 18, 2019·Clinics in Geriatric Medicine·Priti Gros, Aleksandar Videnovic
Sep 2, 2021·Journal of Geriatric Psychiatry and Neurology·Dion A PaulAbdul Qayyum Rana
Sep 25, 2018·Lancet Neurology·Claudia TrenkwalderJuliane Winkelmann

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