Prevalence of serious eosinophilia and incidence of Churg-Strauss syndrome in a cohort of asthma patients

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Jeanne E LoughlinEric S Johnson

Abstract

Some leukotriene receptor antagonists, such as zafirlukast and montelukast, have been associated with systemic eosinophilia, with interest focused on Churg-Strauss syndrome (CSS). To calculate the background incidence rate of CSS and prevalence of eosinophilia among people with asthma who have not used leukotriene receptor antagonists. We conducted a cohort study in the setting of three geographically diverse UnitedHealthcare health plans. We identified 36,230 people who received a diagnosis of asthma during the period October 1994 through September 1997. We identified 241 potential cases from the claims data. Using a standardized hospital record abstract form, nurses abstracted relevant clinical data from the hospital charts of potential cases. We applied several a priori case definitions to the abstracted clinical data and computed incidence rates of CSS among patients with asthma. We additionally used these data to compute the prevalence of serious eosinophilia. Incidence rates of definite CSS among asthma patients ranged from zero (90% confidence interval 0.0 to 23.0) to 67 (90% confidence interval 22.5 to 160.6) cases per 1,000,000 person-years, depending on the definition used. All patients who met the criteria for CSS ex...Continue Reading

References

Aug 1, 1995·Seminars in Arthritis and Rheumatism·R A WattsD G Scott
May 1, 1997·Baillière's Clinical Rheumatology·R A Watts, D G Scott
May 29, 1998·The New England Journal of Medicine·M E Rothenberg
May 30, 1998·QJM : Monthly Journal of the Association of Physicians·A J ReidD G Scott

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Citations

Mar 8, 2011·Clinical Reviews in Allergy & Immunology·Wojciech SzczeklikJacek Musiał
Dec 24, 2002·Current Opinion in Rheumatology·Richard A Watts, David G I Scott
Dec 5, 2006·Current Opinion in Rheumatology·Christian PagnouxLoïc Guillevin
Apr 13, 2007·Drugs·Anjuli Nayak, Ronald B Langdon
Apr 9, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Matthieu GrohLoïc Guillevin
Oct 29, 2011·The Medical Clinics of North America·Evans R Fernández PérezStephen K Frankel
Mar 27, 2007·La Presse médicale·Philippe GuilpainLoïc Guillevin
Aug 30, 2005·Annals of the New York Academy of Sciences·B HellmichW L Gross
Feb 16, 2006·Pediatric Pulmonology·Víctor Manuel Hernández-BautistaFrancisco Espinosa-Rosales
Dec 19, 2003·Expert Opinion on Pharmacotherapy·Bernhard Hellmich, Wolfgang L Gross
Jul 27, 2015·Immunology and Allergy Clinics of North America·Hiromichi TamakiCarol A Langford
Sep 1, 2005·Expert Review of Clinical Immunology·Leif Bjermer
May 19, 2010·Expert Review of Clinical Immunology·Zuzana DiamantLeif Bjermer
May 5, 2009·Chest·Michael E WechslerLisa Lawrence-Miyasaki
Feb 17, 2009·Medicine, Health Care, and Philosophy·Andrew Ward
Sep 8, 2006·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Naomi Tsurikisawa
Feb 7, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Laurie A MankaMichael E Wechsler
Oct 17, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Vamsi P GunturMichael E Wechsler
Apr 6, 2007·La Presse médicale·François Lhote

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