PMID: 9360248Jan 1, 1997Paper

Prevalence of serum antibodies to hantaviruses in northern Sweden as measured by recombinant nucleocapsid proteins

Scandinavian Journal of Infectious Diseases
Clas AhlmF Elgh

Abstract

An enzyme-linked immunosorbent assay (ELISA) based on recombinant nucleocapsid protein (rN delta) (aa 1-117) of Hantaan, Seoul, Dobrava, Sin Nombre and Puumala hantaviruses was used to determine the prevalence of antibodies among randomized and stratified individuals from northern Sweden. In total, 137/1533 individuals (8.9%) had specific serum IgG antibodies to Puumala virus, the only hantavirus known to occur in the region. The prevalence of antibodies to Puumala virus (8.9%) was determined to be higher than previously reported (5.4%) in the same serum material, by use of immunofluorescence assay. As expected, sera reactive to Puumala virus rN delta did frequently cross-react with Sin Nombre virus protein. Unexpectedly, 21/1533 (1.4%) individuals recognized the Sin Nombre virus rN delta exclusively. Another 8 subjects showed reactivity in the ELISA to Hantaan, Seoul, or Dobrava virus-derived rN delta but not Puumala virus or Sin Nombre virus rN delta. The present demonstration in some individuals of antibodies specifically recognizing the Sin Nombre, Dobrava, Hantaan and Seoul virus protein justifies an awareness of the possibility that hantaviruses antigenically different from Puumala virus might occur in the region.

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Citations

Jun 8, 2002·FEMS Immunology and Medical Microbiology·A S PacsaA S Mustafa
Jul 25, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Lourdes LledóAke Lundkvist
Mar 23, 2011·Vector Borne and Zoonotic Diseases·Isabel SanfeliuJosé Vicente Saz
Apr 9, 2010·Clinical Microbiology Reviews·Colleen B JonssonOlli Vapalahti
Aug 2, 2003·Emerging Infectious Diseases·Marlis Täger FreyMarcela G Ferrés
Oct 12, 2002·Journal of Medical Virology·Irina GolovljovaAke Lundkvist
Mar 4, 2009·Expert Review of Anti-infective Therapy·Paul HeymanTatjana Avsic-Zupanc
Jul 21, 2010·Scandinavian Journal of Primary Health Care·Alette BrorstadClas Ahlm

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