PMID: 9360248Jan 1, 1997Paper

Prevalence of serum antibodies to hantaviruses in northern Sweden as measured by recombinant nucleocapsid proteins

Scandinavian Journal of Infectious Diseases
Clas AhlmF Elgh


An enzyme-linked immunosorbent assay (ELISA) based on recombinant nucleocapsid protein (rN delta) (aa 1-117) of Hantaan, Seoul, Dobrava, Sin Nombre and Puumala hantaviruses was used to determine the prevalence of antibodies among randomized and stratified individuals from northern Sweden. In total, 137/1533 individuals (8.9%) had specific serum IgG antibodies to Puumala virus, the only hantavirus known to occur in the region. The prevalence of antibodies to Puumala virus (8.9%) was determined to be higher than previously reported (5.4%) in the same serum material, by use of immunofluorescence assay. As expected, sera reactive to Puumala virus rN delta did frequently cross-react with Sin Nombre virus protein. Unexpectedly, 21/1533 (1.4%) individuals recognized the Sin Nombre virus rN delta exclusively. Another 8 subjects showed reactivity in the ELISA to Hantaan, Seoul, or Dobrava virus-derived rN delta but not Puumala virus or Sin Nombre virus rN delta. The present demonstration in some individuals of antibodies specifically recognizing the Sin Nombre, Dobrava, Hantaan and Seoul virus protein justifies an awareness of the possibility that hantaviruses antigenically different from Puumala virus might occur in the region.


Feb 1, 1987·The Journal of Infectious Diseases·B Niklasson, J W LeDuc
Jan 1, 1988·Scandinavian Journal of Infectious Diseases·A I SommerJ Dalrymple
Oct 1, 1988·The Journal of General Virology·H SheshberadaranE A Tkachenko
Nov 1, 1982·The Journal of Infectious Diseases·H W Lee, K M Johnson
Jan 1, 1983·Scandinavian Journal of Infectious Diseases·B NiklassonJ Dalrymple
Aug 1, 1995·The American Journal of Tropical Medicine and Hygiene·B NiklassonJ Leduc
Feb 1, 1995·Journal of Clinical Microbiology·J HörlingB Niklasson
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·B HjelleA A Scott
Oct 1, 1996·The Journal of General Virology·J HörlingB Niklasson

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