Prevalence of skin allograft discards as a result of serological and molecular microbiological screening in a regional skin bank in Italy

Burns : Journal of the International Society for Burn Injuries
Elisa PianigianiMaurizio Zazzi

Abstract

Postmortem skin is widely used in the treatment of patients with severe burns. Skin specimens must be screened for transmissible agents including human immunodeficiency virus (HIV), hepatitis B (HBV) and C (HCV) virus, human T-cell lymphotropic virus (HTLV), cytomegalovirus (CMV) and Treponema pallidum. Four hundred and sixty-one cadaveric donors underwent serological and molecular microbiological (polymerase chain reaction, PCR) screening at Siena Skin Bank between 2000 and 2004. 74/461 donors (16.1%) were found ineligible under current regulations. These results are interesting in a local context and underline the importance of screening involving both routine serological procedures and molecular microbiological investigation. The latter has not been uniformly introduced in many countries and very limited data is available to assess its cost-benefit ratio in the field of skin donor screening.

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Citations

Nov 28, 2008·Cell and Tissue Banking·Babak ArjmandSoheyla Jebelly far
Mar 12, 2008·The Journal of Trauma·Benita W Britton-ByrdRobert L McCauley
Mar 1, 2011·Burns : Journal of the International Society for Burn Injuries·Michel H E Hermans
Jul 19, 2015·Cirugia y cirujanos·Francisco Martínez-FloresWalter Querevalu-Murillo
Sep 11, 2013·Burns : Journal of the International Society for Burn Injuries·Michel H E Hermans
Aug 16, 2016·Cell and Tissue Banking·C JohnstonUNKNOWN Bioburden Steering Committee and Skin Working group
Sep 27, 2018·BMC Microbiology·Karine Lena MeneghettiGertrudes Corção
Jul 16, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Brecht ValckeWouter Willaert

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