Prevalence of subclinical hypothyroidism in obese children or adolescents and association between thyroid hormone and the components of metabolic syndrome

Journal of Paediatrics and Child Health
Hye Young Jin

Abstract

Subclinical hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) levels with the normal concentrations of thyroxine (T4) or free thyroxine (fT4), and its clinical significance is unclear. The purpose of this study is to investigate the prevalence of subclinical hypothyroidism in children and adolescents and determine the relationship between lipid profiles, insulin resistance and thyroid hormones. A retrospective, cross-sectional study was performed using data from a subset of the KNHANES VI. The subjects whose ages were in the range of 10-19 years were enrolled when their thyroid function tests were available (n = 1104), and their laboratory and anthropometric data were analysed. Subclinical hypothyroidism was more commonly identified in the obese group (27 of 111) compared to the other groups (127 of 993) (24.3 vs. 12.8%, P = 0.002). Total cholesterol and triglyceride levels were higher in a group with subclinical hypothyroidism. Body mass index (BMI) was positively correlated with serum concentrations of the TSH and negatively correlated with serum concentrations of fT4 after adjusting for age. The concentrations of total cholesterol and triglyceride were positively correlated with the TSH concentrations f...Continue Reading

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Citations

Aug 25, 2019·Environmental Health : a Global Access Science Source·Sarah W CurtisMichele Marcus
Aug 17, 2020·Indian Journal of Pediatrics·Riddhi PatelAnurag Bajpai
Sep 2, 2020·Clinical Endocrinology·Ayako KonishiMasanobu Kawai
Apr 11, 2021·Experimental & Molecular Medicine·Eun-Seon YooJong-Woo Sohn
Jan 16, 2021·Clinical and Experimental Pediatrics·Minji KangMinyoung Jung
Aug 16, 2021·Journal of Endocrinological Investigation·A BasoloL Torregrossa

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