Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia

Hormone Research in Pædiatrics
Carolina Taddeo Mendes-Dos-SantosSofia Helena Valente Lemos-Marini

Abstract

Testicular adrenal rest tumors (TART) can cause infertility in congenital adrenal hyperplasia (CAH) males. To determine TART prevalence in patients with CAH due to 21-hydroxylase deficiency (21-OHD) and evaluate possible factors associated with its development. This is a descriptive and analytical cross-sectional study evaluating males with the classical form of 21-OHD through testicular ultrasonography and serum inhibin B dosages. Data on prescribed glucocorticoid dose and serum levels of 17- hydroxyprogesterone (17-OHP), androstenedione (Andro), ACTH, renin, and LH were obtained from medical records. Thirty-eight males were evaluated. The mean age on ultrasonography was 15.2 ± 6.7 (3-27) years. Nine patients (23.7%) had TART, 4 of them were prepubertal and the youngest was 5 years old. No association was found between TART and 21-OHD phenotype, glucocorticoid dose, or 17-OHP, ACTH, LH, renin, and inhibin B levels measured in the 6 preceding years. However, 50% of the patients who presented increased Andro 2 years prior to the evaluation had TART (p = 0.018, OR = 8.00 [95% CI: 1.42-44.92]), whereas in the normal Andro group only 16.7% had tumors. This study showed that TART can occur in prepubertal patients and that disease co...Continue Reading

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Citations

May 11, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gabriela WerneckIvani N Silva
Mar 19, 2019·Endocrine Reviews·Manon EngelsHedi L Claahsen-van der Grinten
May 8, 2021·Endocrine Reviews·Hedi L Claahsen-van der GrintenPerrin C White
Nov 11, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mohammed Ayed HuneifAbdulhameed AlSaheel
Nov 12, 2021·Archives of Endocrinology and Metabolism·Ronit KorenZvi Vaknin

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