Prevalence of the Academic Research Consortium for High Bleeding Risk Criteria and Prognostic Value of a Simplified Definition.

Circulation Journal : Official Journal of the Japanese Circulation Society
Katsuya MiuraKazushige Kadota

Abstract

The Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria have been suggested as the standard definition of HBR. However, the prevalence of individual criteria and their prognostic value for long-term bleeding events after percutaneous coronary intervention are scarcely studied.Methods and Results:The study population comprised 1,193 patients treated with everolimus-eluting stents between 2010 and 2011. Data on all 17 major and minor criteria of the ARC-HBR definition were retrospectively collected, and applied to this study population. Major bleeding was defined as the occurrence of a BARC type 3 or 5 bleeding event. A simplified definition was developed by excluding the low-frequency criterion, and the prognostic value was assessed by a receiver-operating characteristic curve. Mean follow-up was 2,996±433 days and there were 656 HBR patients (55.0%). The cumulative incidence of major bleeding was significantly higher in the HBR group than in the non-HBR group (16.2% vs. 5.7% at 8 years, P<0.001). The frequencies of 6 of the 17 criteria were less than 1%. The prognostic value of the simplified definition made by excluding these 6 criteria for major bleeding was comparable to that of the original (c-statistic=0...Continue Reading

References

May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Nov 18, 2014·The New England Journal of Medicine·Laura MauriUNKNOWN DAPT Study Investigators
Mar 20, 2015·Journal of the American College of Cardiology·Robert W YehUNKNOWN DAPT Study Investigators
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Apr 2, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuo KimuraUNKNOWN Japanese Circulation Society Joint Working Group
Sep 10, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Katsuya MiuraKazushige Kadota
Nov 12, 2019·Circulation. Cardiovascular Interventions·Donald E Cutlip, Philip Urban
Dec 18, 2019·Cardiovascular Intervention and Therapeutics·Yuichi SaitoYuji Ikari
Jan 24, 2020·Cardiovascular Intervention and Therapeutics·Antonio MangieriAntonio Colombo
Feb 18, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Yasushi UekiLorenz Räber
Mar 17, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Masato NakamuraAtsushi Hirayama

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Citations

Feb 20, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Giuseppe Gargiulo, Giovanni Esposito
Mar 21, 2021·Heart and Vessels·Yohei SotomiUNKNOWN Osaka Acute Coronary Insufficiency Study (OACIS) Group
Apr 16, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichi Saito, Yoshio Kobayashi
Oct 29, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yu SatoYasuchika Takeishi

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