Prevalence of the immune evasion gene cluster in Staphylococcus aureus CC398

Veterinary Microbiology
Christiane CunyWolfgang Witte

Abstract

The immune evasion gene cluster (IEC) is typical for Staphylococcus aureus isolated from humans but is usually absent in S. aureus isolated from animals. Previous studies have shown that methicillin resistant S. aureus (MRSA) CC398 obviously lost the IEC when evolving as livestock-associated MRSA from a human-adapted, methicillin-susceptible ancestor. This study aimed to look for the presence of IEC in MRSA from pigs and horses as well as from the colonization of humans with occupational animal contact and from infections in humans. For comparison, methicillin susceptible S. aureus (MSSA) isolates from infections in humans were included. We did not detect the IEC among 94 isolates from the nasal colonization of pigs; however, the IEC was found in 6 of 61 isolates from nosocomial infections in horses. MRSA CC398 isolates from the nasal colonization of 138 pig farmers were negative for the IEC. It was detected, however, in 4 of 69 veterinarians treating horses. Among 99 epidemiologically unrelated MRSA isolates attributed to CC398 originating from infections in humans, 19 were positive for the IEC. Only three of these isolates which also contained luk-PV were attributed to the ancestral, human-adapted subpopulation of CC398 by me...Continue Reading

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Citations

Feb 13, 2016·Veterinary Microbiology·Christiane Cuny, Wolfgang Witte
May 30, 2016·Veterinary Microbiology·Britta BallhausenKarsten Becker
Feb 8, 2018·The Journal of Biological Chemistry·Nienke W M de JongSuzan H M Rooijakkers
Feb 17, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Angeles ArgudínS Roisin
Jan 1, 2015·Antibiotics·Christiane CunyWolfgang Witte
Feb 6, 2017·PloS One·Aneta MroczkowskaJoanna Empel
Mar 28, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H ParidaensO Denis
Feb 27, 2019·EFSA Journal·UNKNOWN European Food Safety Authority, UNKNOWN European Centre for Disease Prevention and Control
Sep 14, 2018·Clinical Microbiology Reviews·Sahreena Lakhundi, Kunyan Zhang
Sep 3, 2020·EFSA Journal·UNKNOWN European Food Safety Authority, UNKNOWN European Centre for Disease Prevention and Control
Jun 8, 2017·Antibiotics·Maria Angeles ArgudínSandrine Roisin
Feb 23, 2017·EFSA Journal·UNKNOWN European Food Safety Authority, UNKNOWN European Centre for Disease Prevention and Control
Feb 27, 2018·EFSA Journal·UNKNOWN European Food Safety Authority, UNKNOWN European Centre for Disease Prevention and Control
Nov 11, 2020·Microorganisms·Kevin BouillerCatherine Chirouze
Apr 19, 2021·Journal of Global Antimicrobial Resistance·Cheng ChenGuiqin Wang
Apr 20, 2021·EFSA Journal·UNKNOWN European Food Safety Authority, UNKNOWN European Centre for Disease Prevention and Control
Aug 14, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Theodoros KarampatakisAnna Papa

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