Prevalence of thyroid malignancy and hormonal dysfunction following radiation exposure in childhood.

Annals of the Academy of Medicine, Singapore
Yee Sian TiongSamantha Peiling Yang

Abstract

Childhood radiation exposure is a known risk factor for thyroid malignancy and dysfunction. However, local data are limited and there is no consensus on the modality and frequency of screening in this high-risk group. Retrospective analysis study evaluating patients with childhood radiation exposure in 2006-2016 and minimum of 1-year follow-up. Of the 132 childhood cancer survivors in the study, thyroid malignancy was detected in 2 cases (1.5%) and thyroid nodules in 13 (9.8%). The earliest thyroid malignancy was detected 5 years post-radiotherapy via ultrasound. Of the 84 patients who had screening thyroid function test, 26 (31.0%) were detected with abnormal test results post-radiation, majority being subclinical hypothyroidism. Regular screening via clinical examination for thyroid nodules should be performed at least annually. Where feasible and if resources permit, consideration should be given to using ultrasound for thyroid nodule(s) and malignancy screening at 5 years post-radiation therapy. Screening for thyroid dysfunction can be considered from 6-12 months post-radiotherapy.

References

Dec 22, 1999·Archives of Internal Medicine·F de VathaireC Bonaïti
Aug 22, 2000·European Journal of Nuclear Medicine·B JarzabZ Puch
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Hossein Gharib, Enrico Papini
Nov 1, 2007·Journal of the National Cancer Institute·Anil K ChaturvediLois B Travis
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Ibrahima DialloFlorent de Vathaire
Apr 9, 2010·Thyroid : Official Journal of the American Thyroid Association·Clodagh S O'GormanDenis Daneman
Jun 13, 2013·JAMA : the Journal of the American Medical Association·Melissa M HudsonLeslie L Robison
Sep 23, 2014·Journal of Clinical Research in Pediatric Endocrinology·Ayla Akca CağlarHüseyin Bora
Apr 4, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Siobhan M PhillipsAngela B Mariotto
Apr 23, 2015·Thyroid : Official Journal of the American Thyroid Association·Gary L FrancisUNKNOWN American Thyroid Association Guidelines Task Force
Sep 4, 2015·The Journal of Clinical Endocrinology and Metabolism·Florent de VathaireCarole Rubino
Jan 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Enrico BrignardelloNicola Palestini
Jan 26, 2016·European Journal of Pediatrics·Wei Li Cindy Ho, Margaret R Zacharin
May 12, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hossein GharibUNKNOWN AACE/ACE/AME Task Force on Thyroid Nodules
Dec 29, 2016·Journal of Cancer Survivorship : Research and Practice·Emily S TonorezosKevin C Oeffinger
Jan 18, 2017·OncoTargets and Therapy·Frederik A VerburgMarkus Luster

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologów Dziecięcych
Katarzyna ZioraWojciech Zajecki
© 2021 Meta ULC. All rights reserved