Prevalence of tuberculosis infection and disease in children referred for tuberculosis medical surveillance in Ontario: a single-cohort study

CMAJ Open
Catherine YangIan Kitai

Abstract

There are few data about the utility of the Canadian tuberculosis medical surveillance system for detecting tuberculosis in children and adolescents. We sought to assess the prevalence of tuberculosis infection and disease in children and adolescents referred by the tuberculosis medical surveillance program who were evaluated at The Hospital for Sick Children (SickKids) tuberculosis program. We retrospectively studied clinical records, radiographic findings and results of interferon-γ release assays (IGRAs) of all children less than 18 years of age referred by the tuberculosis medical surveillance program and evaluated at SickKids between November 2012 and June 2016. The median age of the 216 children was 10.0 years. Most were born in the Philippines (157 [72.7%]) or India (39 [18.0%]). Of the 216, 166 (76.8%) had a history of prior treatment for tuberculosis, and 34 (15.7%) were federal-sponsored refugees from settings with a high tuberculosis burden. Negative IGRA results were found in 110/130 (84.6%) of those with prior tuberculosis treatment. Thirty-one children (14.4%) had any chest radiographic abnormality, of whom 4 had changes thought to be due to tuberculosis. No child received a diagnosis of active tuberculosis at ass...Continue Reading

References

Nov 1, 1983·American Journal of Diseases of Children·K H Hsu
Feb 13, 2002·The Pediatric Infectious Disease Journal·Fahad S Al-DossaryJeffrey R Starke
Feb 25, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nira R PollockAntonio Campos-Neto
Sep 30, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kamran KhanElizabeth Rea

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Citations

Jun 29, 2021·The Cochrane Database of Systematic Reviews·Bryan VonasekAnna M Mandalakas

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