Prevalence of venous thromboembolism at pretreatment screening and associated risk factors in 2086 patients with gynecological cancer.

The Journal of Obstetrics and Gynaecology Research
Nobutaka TasakaToyomi Satoh

Abstract

Postoperative pulmonary embolism can be a fatal surgical complication and is thought to occur secondary to asymptomatic venous thromboembolism (VTE) that exists preoperatively in some patients. The purpose of this study was to clarify the frequency and risk factors of pretreatment VTE in gynecological cancer patients. This study investigated 2086 patients with gynecological cancer (cervix, n = 754; endometrium, n = 862; ovary, n = 470) who underwent initial treatment between 2004 and 2017. Pretreatment VTE screening was performed with D-dimer (DD) levels in these patients. Based on this, the associated risk factors were retrospectively analyzed. Pretreatment VTE was discovered in 7.3% of patients with cervical cancer, 11.5% of those with endometrial cancer and 27.0% of those with ovarian cancer. Significant independent risk factors were: age greater than or equal to 60 years and tumor long diameter greater than or equal to 40 mm for cervical cancer; age greater than or equal to 60 years, stage III/IV advanced disease, clear cell carcinoma and tumor long diameter greater than or equal to 60 mm for endometrial cancer; and age greater than or equal to 60 years, clear cell carcinoma and massive ascites for ovarian cancer. Pretreatm...Continue Reading

References

Sep 26, 2003·The New England Journal of Medicine·Philip S WellsMichael J Kovacs
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Dec 1, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiangxiang WuRongyu Zang
Dec 25, 2012·Gynecologic Oncology·Koji MatsuoLynda D Roman
Mar 11, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Manabu SakuraiHiroyuki Yoshikawa
Oct 19, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Manabu SakuraiToyomi Satoh
May 16, 2017·Gynecologic Oncology·Joshua G CohenChristine S Walsh

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