Prevalence of vitamin D deficiency in HIV-positive, antiretroviral treatment-naïve patients in a single centre study

International Journal of STD & AIDS
Keerti GedelaAlison D Grant

Abstract

The objective of this study was to describe the prevalence of vitamin D deficiency among antiretroviral treatment-naïve, HIV-positive individuals. We reviewed records of consecutive antiretroviral treatment-naïve patients, registering for care for the first time at a London clinic from 01 January 2008 to 31 December 2009. During this period, serum 25-hydroxycholecalciferol was measured routinely for all new patients. 25-hydroxycholecalciferol deficiency and severe deficiency were defined as ≤50 and ≤25 nmol/L, respectively. Among 253 patients (82% men, median age 36 years, 64% white ethnicity), 148 (58.5%) were 25-hydroxycholecalciferol-deficient, including 32 (12.6%) who were severely deficient. In all, 73.5% (61/83) patients of non-white ethnicity were 25-hydroxycholecalciferol-deficient compared with 50.7% (76/150) of those reporting white ethnicity (p < 0.001). Seven of eight (87.5%) patients with hypocalcaemia (<2.12 nmol/L) were 25-hydroxycholecalciferol-deficient. The prevalence of 25-hydroxycholecalciferol-deficiency was higher in winter and spring vs. summer and autumn (89/129 [69.0%] vs. 59/124 [47.6%],p < 0.001). Serum 25-hydroxycholecalciferol deficiency was not associated with gender, CD4 count, HIV viral load or c...Continue Reading

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Citations

May 23, 2015·BioMed Research International·Pasquale MansuetoAntonio Cascio
Mar 30, 2016·Current Opinion in HIV and AIDS·Flavia Kiweewa MatovuKiat Ruxrungtham
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Gerome V EscotaWilliam G Powderly
Sep 14, 2018·Calcified Tissue International·María Elena CeballosGilberto González
Feb 19, 2016·Current Opinion in HIV and AIDS·Corrilynn O HilemanGrace A McComsey
Aug 14, 2020·Journal of the American College of Nutrition·Shinwon LeeSun Hee Lee

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