Prevalence of wild type transtyrethin cardiac amyloidosis in a heart failure clinic.

ESC Heart Failure
Krister LindmarkPer Lindqvist

Abstract

Wild type transthyretin amyloidosis (ATTRwt) has gained interest during recent years due to better diagnostic tools and the emergence of treatment options. Little is known about the prevalence of the disease. We aimed to investigate the prevalence in a heart failure population with myocardial hypertrophy. All patients with an ICD code of heart failure living within the catchment area of Umeå University hospital and intraventricular septum >14 mm were offered screening with 3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and a clinical work up. Out of 2238 patients with heart failure, 174 patients were found to have a septum >14 mm. Ten patients were already diagnosed with hereditary ATTR cardiomyopathy, 12 patients had ATTRwt cardiomyopathy, 12 patients had known HCM, one patient had AL amyloidosis, and four patients had already undergone a negative DPD scan (DPD uptake grade 0 and 1) within the last 3 years. This left 134 patients who we tried to contact for screening, but 48 patients had either died or declined to participate. Out of 86 screened patients, 13 had a DPD uptake of grade 2 or 3 without other amyloid disease making the total number of patients with ATTRwt in this population 25. Approximately 20% of investi...Continue Reading

References

Sep 1, 1965·British Heart Journal·A Pomerance
Sep 20, 2005·Journal of the American College of Cardiology·Enrica PeruginiClaudio Rapezzi
Jan 30, 2010·Progress in Cardiovascular Diseases·Rodney H Falk, Simon W Dubrey
Apr 24, 2013·Journal of the American Heart Association·Jennifer H PinneyHelen J Lachmann
Aug 1, 2015·European Heart Journal·Esther González-LópezPablo Garcia-Pavia
May 5, 2016·Circulation·Julian D GillmorePhilip N Hawkins
Jul 9, 2016·Journal of the American College of Cardiology·Mathew S MaurerUNKNOWN THAOS Investigators
Apr 25, 2017·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Ole B SuhrIntissar Anan
Aug 28, 2018·The New England Journal of Medicine·Mathew S MaurerUNKNOWN ATTR-ACT Study Investigators
Feb 19, 2019·American Journal of Hematology·M Hasib SidiqiAngela Dispenzieri
Jul 25, 2019·European Journal of Heart Failure·Marco CanepaStefano Perlini
Aug 21, 2020·European Journal of Clinical Pharmacology·Helena NorbergKrister Lindmark

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Citations

Mar 30, 2021·Drug Design, Development and Therapy·Arianna BurtonJeffery W Kelly
May 26, 2021·Clinical Physiology and Functional Imaging·Viktor LöfbackaPer Lindqvist

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Methods Mentioned

BETA
biopsies

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