PMID: 11318812Apr 25, 2001Paper

Prevalence of Yersinia plasmid-encoded outer protein (Yop) class-specific antibodies in patients with Hashimoto's thyroiditis

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
S ChatzipanagiotouC Nicolaou

Abstract

To investigate the prevalence of class-specific antibodies (IgG, IgA) to Yersinia enterocolitica plasmid-encoded outer proteins (Yops) in patients with diagnosed Hashimoto's thyroiditis. Seventy-one patients with Hashimoto's disease, 464 healthy blood donors and 250 patients with non-postinfectious rheumatic disorders (matched controls) were tested for class-specific antibodies to Yops. Anti-Yop antibodies were determined by ELISA and Western blot. The prevalence of class-specific antibodies to Yops as determined by ELISA was 14-fold higher (20 of 71; 28.2%) in people with Hashimoto's thyroiditis than in the two control groups. These results were confirmed by the Western blot, with 16 positive sera, three equivocal and one negative. There is strong clinical and seroepidemiologic evidence for an immunopathologic causative relationship between Yersinia enterocolitica infection and Hashimoto's thyroiditis. Further investigation concerning the mechanisms involved and the possible effects of antibacterial chemotherapy on the outcome of Hashimoto's disease is warranted.

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Citations

Nov 22, 2005·Folia Microbiologica·A SonnevendT Pál
Apr 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Salvatore Benvenga, Francesco Trimarchi
Jan 7, 2011·Journal of Thyroid Research·Marco CappaFrancesca Crea
Dec 5, 2006·Rheumatology International·María G LacosteMaría S Di Genaro
Jun 17, 2016·Reviews in Endocrine & Metabolic Disorders·Salvatore Benvenga, Fabrizio Guarneri
Dec 22, 2009·Journal of Autoimmunity·Yaron Tomer
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Fabrizio Guarneri, Salvatore Benvenga
Aug 23, 2019·Kidney Research and Clinical Practice·Ye Kyung KimHee Gyung Kang

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