Prevalence, pathogenesis, and causes of chronic cough

Lancet
Kian Fan Chung, I D Pavord

Abstract

Cough is a reflex action of the respiratory tract that is used to clear the upper airways. Chronic cough lasting for more than 8 weeks is common in the community. The causes include cigarette smoking, exposure to cigarette smoke, and exposure to environmental pollution, especially particulates. Diseases causing chronic cough include asthma, eosinophilic bronchitis, gastro-oesophageal reflux disease, postnasal drip syndrome or rhinosinusitis, chronic obstructive pulmonary disease, pulmonary fibrosis, and bronchiectasis. Doctors should always work towards a clear diagnosis, considering common and rare illnesses. In some patients, no cause is identified, leading to the diagnosis of idiopathic cough. Chronic cough is often associated with an increased response to tussive agents such as capsaicin. Plastic changes in intrinsic and synaptic excitability in the brainstem, spine, or airway nerves can enhance the cough reflex, and can persist in the absence of the initiating cough event. Structural and inflammatory airway mucosal changes in non-asthmatic chronic cough could represent the cause or the traumatic response to repetitive coughing. Effective control of cough requires not only controlling the disease causing the cough but also ...Continue Reading

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References

Mar 22, 1979·The New England Journal of Medicine·W M CorraoR S Irwin
Feb 1, 1990·The American Review of Respiratory Disease·M HeinoL A Laitinen
Nov 1, 1989·The American Review of Respiratory Disease·R S IrwinP J Hoffman
Jun 18, 1988·British Medical Journal·R C Brown, C W Turton
Feb 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G GibsonJ Dolovich
Mar 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S F DavisS L Cochi
Jan 1, 1995·The Journal of Allergy and Clinical Immunology·C BuccaM D'Alberto
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·M FerrariV Lo Cascio
Aug 1, 1994·American Journal of Respiratory and Critical Care Medicine·F O'ConnellR W Fuller
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·A J IngA B Breslin
Nov 15, 1993·Annals of Internal Medicine·M R PratterJ DuBois
Feb 1, 1993·Journal of Epidemiology and Community Health·P Cullinan
Jan 1, 1997·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M FujimuraT Matsuda
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·S B GordonA H Morice
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·I K CarneyM J Hensley
Jul 2, 1998·The European Respiratory Journal·A NiimiF Kuze
Aug 19, 2000·Lancet·A NiimiR Amitani
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·C E BrightlingI D Pavord
Nov 18, 2000·Thorax·M J DohertyP M Calverley
Feb 24, 2001·Thorax·L M OsmanJ G Douglas
Mar 10, 2001·Respiration Physiology·E S Schelegle, J F Green
Oct 24, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Dan WeinfeldEva Millqvist
Aug 15, 2003·American Journal of Respiratory and Critical Care Medicine·Benjamin D M Hope-GillNicholas K Harrison
Jan 1, 1954·The Journal of Physiology·J G WIDDICOMBE
Sep 27, 2003·American Journal of Respiratory and Critical Care Medicine·Surinder S BirringIan D Pavord
Oct 1, 2003·The European Respiratory Journal·I CerveriUNKNOWN ISAYA Study Group
Mar 9, 2004·The Journal of Physiology·Brendan J CanningBradley J Undem

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Citations

Aug 22, 2009·Lung·Lorcan McGarvey
Nov 29, 2011·Lung·Omer Van den BerghPaul W Davenport
Jan 29, 2013·Annals of Biomedical Engineering·Vinayak SwarnkarRina Triasih
Mar 20, 2012·Acta neurologica Belgica·Emine TosunBehiye Akkalyoncu
Sep 10, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S MehiriF Mornex
Feb 24, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Srinivasan Ramanuja, Pramod Kelkar
Oct 14, 2008·Journal of Toxicology and Environmental Health. Part a·Bernadette M Longo, Wei Yang
Aug 6, 2009·Nuclear Medicine Communications·Aysen Bingol BozFirat Gungor
Apr 19, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery·Ryan PalmerPhil Gallagher
Jul 2, 2011·International Journal of Clinical Practice·R A Cathcart, J A Wilson
Oct 27, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·Felix Holzinger, Jean-François Chenot
Jul 1, 2011·Therapeutic Advances in Chronic Disease·Jaymin B Morjaria, Jack A Kastelik
May 26, 2009·Respiratory Research·Shaoping XieKian Fan Chung
Jan 11, 2012·Health and Quality of Life Outcomes·Farida F BerkhofJan W K van den Berg
Oct 12, 2011·Cough·Francesco De BlasioLuigi Lanata
Nov 2, 2012·Cough·Charlotte Van de KerkhoveLieven J Dupont
Dec 4, 2013·Cough·Heikki O Koskela, Minna K Purokivi
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Chiara MagniAlessandro Zanasi
Nov 10, 2013·PloS One·Woo-Jung SongYoon-Seok Chang
Aug 8, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Stephanie Tatzel, Alp Sener
Nov 5, 2011·Asia Pacific Allergy·Hye-Young KimSang-Il Lee
Dec 16, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Krishna M Sundar, Sarah E Daly
Jun 3, 2014·Deutsches Ärzteblatt International·Felix HolzingerChristoph Heintze
Feb 15, 2014·Asia Pacific Allergy·Woo-Jung SongAlyn H Morice
Jan 17, 2014·The Lancet. Respiratory Medicine·Kian Fan ChungStuart B Mazzone
Jun 13, 2014·Wiener klinische Wochenschrift·Angela ZacharasiewiczUNKNOWN Austrian Society of Pediatrics and The Austrian Society of Pneumology
Jun 1, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Thomas KjærgaardSverre K Steinsvåg
Feb 20, 2016·Singapore Medical Journal·Vijo PouloseChoon How How
Jan 12, 2016·International Journal of Environmental Research and Public Health·Thao Thi Thu NguyenHiroyuki Nakamura
Feb 3, 2016·BMC Complementary and Alternative Medicine·Kwan-Il KimJunhee Lee
Apr 4, 2015·Journal of Psychosomatic Research·Norihiro SaitoHiroyuki Kayaba
Nov 19, 2015·Orphanet Journal of Rare Diseases·Laura L TosiFergus E McKiernan
Dec 17, 2015·Journal of Ethnopharmacology·Kwan-Il KimHyangsook Lee

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