Prevalence, Predictors and Prognosis of Post-Stroke Hyperglycaemia in Acute Stroke Trials: Individual Patient Data Pooled Analysis from the Virtual International Stroke Trials Archive (VISTA).

Cerebrovascular Diseases Extra
Keith W MuirMyzoon Ali

Abstract

Post-stroke hyperglycaemia (PSH) is associated with higher mortality and dependence, but further data on predictors of PSH and its evolution over time are required. We examined the prevalence, predictors, and prognosis of acute PSH using data from well-characterised clinical trials in the VISTA database. Data were extracted for individual participants enrolled <24 h after stroke with ≥1 blood glucose readings documented. PSH was defined as glucose >7.0 mmol/l. Outcome measures were: (1) prevalence of PSH; (2) predictors of PSH by binary logistic regression; (3) mortality, and (4) favourable functional outcome [modified Rankin Scale (mRS) score <2] at day 90. For 2,649 subjects treated at a median 5.5 h after admission, PSH was present in 1,126 (42.6%, 95% CI 40.7-44.5) on admission and within the first 48 h in 1,421 (53.7%, 95% CI 51.8-55.6). PSH developed between 24 and 48 h in 19.4% (95% CI 17.5-21.4) of initially normoglycaemic subjects. Admission and 48-hour PSH were predicted predominantly by a history of diabetes (for admission PSH: OR 7.40, 95% CI 5.60-9.79) and less clearly by stroke severity. Favourable outcome (mRS <2) at day 90 was less likely with PSH within the first 48 h, advanced age, and higher NIHSS score, and ...Continue Reading

Citations

May 30, 2009·Stroke; a Journal of Cerebral Circulation·Jeffrey L SaverUNKNOWN STAIR VI Consortium
Feb 25, 2011·Neurology·D DowlatshahiUNKNOWN VISTA Collaboration
Jul 9, 2014·Journal of Thrombosis and Thrombolysis·Blanca FuentesExuperio Díez-Tejedor
Jul 11, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David TarrDeborah Dewar
Sep 17, 2008·Handbook of Clinical Neurology·Patrik Michel
Jul 19, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Claire MullerChristopher Bladin
May 21, 2017·Stroke; a Journal of Cerebral Circulation·Jean-Philippe DesillesBenoit Ho-Tin-Noé
Feb 20, 2019·Stroke; a Journal of Cerebral Circulation·Ángel ChamorroUNKNOWN HERMES Collaborators
Aug 5, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN METACOHORTS Consortium. Electronic address: joanna.wardlaw@ed.ac.uk, UNKNOWN METACOHORTS Consortium
Aug 11, 2017·Neurology·Terence J QuinnUNKNOWN VISTA Collaborators
Aug 20, 2018·Brain and Neuroscience Advances·Lisa A ThowDeborah Dewar
Apr 23, 2019·European Stroke Journal·Blanca FuentesUNKNOWN European Stroke Organisation
Apr 17, 2020·Stroke; a Journal of Cerebral Circulation·Takuya SaitoUNKNOWN RESCUE-Japan Registry 2 Investigators

❮ Previous
Next ❯

Software Mentioned

VISTA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.