Prevalence, treatment modalities and prognosis of familial prostate cancer in a screened population

The Journal of Urology
Stijn RoemelingFritz H Schröder

Abstract

A family history of prostate cancer is an important risk factor for this disease. The clinical presentation and prognosis of familial disease remain uncertain. In this study these entities are evaluated in the first and second rounds of a screening program in The Netherlands. Of all men randomized in the Rotterdam section of the ERSPC, 19,970 men were eligible for screening. Information regarding the family history was obtained by a self-administered questionnaire at baseline. In the prevalence screen the cancer detection rate in 1,364 men (7.1%) with a positive family history was 7.7% (106 cancers in 1,364 screened men with a positive family history) while the positive predictive value of the biopsies was 32.2% (154 cancers of 532 biopsies). In 12,803 sporadic cases the detection rate was 4.7% and the positive predictive value was 23.6% (p <0.0001 and 0.003, RR 1.63). No clinicopathological differences were found in the 1,559 men diagnosed in the first and second rounds. The overall biochemical-free survival rate after a mean followup of 56.8 months (range 0 to 129.9) was 76.8%, and was not significantly different in familial and sporadic cases (p = 0.840). These findings were consistent for the specific treatment modalities a...Continue Reading

References

Sep 1, 1993·The Journal of Urology·B S CarterP C Walsh
Oct 1, 1996·British Journal of Urology·P J McCahyD E Neal
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A KupelianE A Klein
Nov 5, 1997·Epidemiology·C RodríguezC W Heath
Nov 20, 1997·The Journal of Urology·P A KupelianJ H Suh
Feb 25, 1999·International Journal of Radiation Oncology, Biology, Physics·M C HanusA Pollack
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O BrattH Olsson
May 7, 2002·The Journal of Urology·O BrattH Grönberg
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tuukka MäkinenAnssi Auvinen
Jul 24, 2003·European Urology·Laurence ColletteUNKNOWN EORTC Genito-Urinary Group
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Michael E RayHoward M Sandler
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani

❮ Previous
Next ❯

Citations

Jul 24, 2012·World Journal of Urology·Roberto L MullerStephen J Freedland
Sep 16, 2010·Molecular Biology Reports·Yu ZhuJun-Qing Zhang
Mar 22, 2008·The Journal of Urology·Hiroshi HirataRajvir Dahiya
Nov 21, 2007·Pathology·David S LambBrett Delahunt
Nov 4, 2016·International Journal of Cancer. Journal International Du Cancer·Myeongjee LeeKamila Czene
Apr 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kari HemminkiPer Lenner
Sep 8, 2018·Journal of Cellular Physiology·Mehran PashirzadSeyed Mahdi Hassanian
Feb 24, 2011·Korean journal of urology·Seung Hwan LeeByung Ha Chung
Oct 25, 2007·International Journal of Cancer. Journal International Du Cancer·Lambertus A KiemeneyHans F Vasen
Mar 16, 2019·Journal of Cellular and Molecular Medicine·Zhengfei ShanDongfu Liu
Mar 30, 2013·British Journal of Cancer·K UenoR Dahiya
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroshi HirataRajvir Dahiya
Jan 21, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joke BeutenRobin J Leach
Mar 20, 2020·Current Pharmaceutical Biotechnology·Jun DengSuping Cui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.