Prevalence, trends and in-hospital outcomes of takotsubo syndrome among United States cannabis users

International Journal of Cardiology
Rupak DesaiRajesh Sachdeva

Abstract

Recent reports suggest a link between increased cannabis (marijuana) use and stress-cardiomyopathy (Takotsubo Syndrome, TTS) and related complications. Amidst recent trends in cannabis legalization and a paucity of data, it remains essential to evaluate the prevalence, trends and outcomes of TTS in cannabis users on a large-scale. We studied prevalence and trends in TTS among adult cannabis users vs. non-users using the National Inpatient Sample (2007-2014). Baseline characteristics, comorbidities, and in-hospital outcomes of TTS were compared between cannabis users vs. non-users. Weighted logistic regression was performed adjusting for confounders to estimate the inpatient outcomes of TTS with vs. without cannabis use. The overall prevalence of TTS in cannabis users (47/100,000) was lower as compared to non-users (62/100,000). Rising trends in TTS among cannabis users (<11 to 82, ~8-fold) were more pronounced as compared to non-users (19 to 108, ~6 fold) per 100,000 hospitalizations from 2007 to 2014 (ptrend<0.001). Of all inpatient encounters for TTS (n=156,506), 1565 (0.1%) reported cannabis use. Polysubstance use including alcohol (4.1% vs. 24.4%), cocaine (0.4% vs. 8.5%), amphetamine (0.2% vs. 8.0%), and smoking (31.2% vs....Continue Reading

References

Mar 18, 2015·Clinical Pharmacology and Therapeutics·W Hall, M Weier
Dec 22, 2015·Addiction·Rosalie Liccardo PaculaErvant J Maksabedian
Aug 13, 2017·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Marco Giuseppe Del BuonoAntonio Abbate
Sep 15, 2017·Nature Reviews. Cardiology·Pal PacherGeorge Kunos
Dec 5, 2019·Frontiers in Pediatrics·Laura BucchinoSimonetta Bellone

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Citations

Mar 18, 2021·Future Cardiology·Ibrahim El-BattrawyIbrahim Akin

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