Prevalences of Pneumocystis jiroveci, Mycobacterium tuberculosis and Streptococcus pneumoniae infection in children with severe pneumonia, in a tertiary referral hospital in northern Tanzania

Annals of Tropical Medicine and Parasitology
J UriyoT D McHugh

Abstract

At the Kilimanjaro Christian Medical Centre, a tertiary referral hospital in northern Tanzania, both the number of paediatric cases of lower respiratory-tract infection (LRTI) and the associated mortality increased between 2000 and 2001. Molecular diagnostic tools were used to enhance the identification of the pathogens responsible for this perceived increase. All 72 children aged between 2 and 60 months who were admitted with LRTI over a 3-month period were enrolled in the study. Induced sputum was collected from each child and, if the parents consented, the subjects were also tested for HIV. The sputum samples were each checked for bacteria by culture and, in amplification assays, for the DNA of Pneumocystis jiroveci, Mycobacterium tuberculosis and Streptococcus pneumoniae. Twenty-two (50%) of the 44 children tested for HIV had HIV-1 antibodies. Although only two children, both aged <6 months, were found PCR-positive for P. jiroveci, and only one was found positive for M. tuberculosis, 46 (including one of those found positive for P. jiroveci and the child found positive for M. tuberculosis) were found PCR-positive for S. pneumoniae. It therefore appears that most paediatric cases of LRTI who present at the hospital are attri...Continue Reading

References

Aug 5, 2000·The Pediatric Infectious Disease Journal·H J ZarG Hussey
Feb 28, 2002·Journal of Medical Microbiology·Steven Obaro, Richard Adegbola
May 9, 2002·British Medical Bulletin·Stephen M Graham, Diana M Gibb
Sep 8, 2005·Journal of Clinical Microbiology·Nathalie BastienYan Li

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Citations

Jul 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heather J ZarMark P Nicol
Nov 3, 2007·The Lancet Infectious Diseases·Sandra J BlissOrin S Levine
Mar 3, 2010·Expert Review of Anti-infective Therapy·Heather J ZarMark Nicol

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