Prevalent cerebrovascular and cardiovascular disease in people with Parkinson's disease: a meta-analysis

Clinical Epidemiology
Chien Tai HongChyi-Huey Bai

Abstract

People with Parkinson's disease (PwP) are speculated to be at a low risk of cerebrovascular and cardiovascular disease (CVD) because they have fewer vascular risk factors and lower smoking rate. However, emerging evidence suggests that PwP are at higher risk of CVD, which introduces controversy to the notion that there is no association between Parkinson's disease (PD) and CVD. Hence, we conducted a meta-analysis to analyze the risk of CVD in PwP. Electronic databases were searched using terms related to PD and CVD. Articles were included in the meta-analysis only if they employed clear diagnostic criteria for PD and CVD. The reference lists of the relevant articles were reviewed to identify eligible studies not found during the keyword search. The enrolled studies were categorized into case-control and cohort studies, and the former was further divided into postmortem (three) and clinical (four) studies. In the clinical case-control studies group, PD was more associated with CVD (OR: 2.89, 95% CI: 1.36-6.13). Three studies were enrolled in the cohort studies group, and the merged results demonstrated that PwP were at higher risk of CVD during the follow-up period (HR: 1.84, 95% CI: 1.34-2.54). PD is associated with CVD, which ...Continue Reading

Citations

Apr 30, 2020·Journal of Movement Disorders·Roongroj BhidayasiriSun-Ju Chung
Sep 10, 2020·International Journal of Molecular Sciences·Shubhra AcharyaYvan Devaux
Apr 3, 2019·Drugs & Aging·Martin KlietzGünter U Höglinger
Nov 24, 2020·Oxidative Medicine and Cellular Longevity·Natalia Jimenez-Moreno, Jon D Lane
Feb 21, 2021·Molecular Neurobiology·Efthalia AngelopoulouChristina Piperi
Dec 8, 2021·The Neuroradiology Journal·Mariana AlvesSofia Reimão

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